The usual dosage of CANASA® (mesalamine, USP) 1000 mg suppositories is one rectal suppository 1 time daily at bedtime.
The suppository should be retained for one to three hours or longer, if possible, to achieve the maximum benefit. While the effect of CANASA® suppositories may be seen within three to twenty-one days, the usual course of therapy would be from three to six weeks depending on symptoms and sigmoidoscopic findings. Studies have suggested that CANASA® suppositories will delay relapse after the six-week short-term treatment.
Patient Instructions:
NOTE: CANASA® suppositories will cause staining of direct contact surfaces, including but not limited to fabrics, flooring, painted surfaces, marble, granite, vinyl, and enamel.
Detach one suppository from strip of suppositories.
Hold suppository upright and carefully remove the plastic wrapper.
Avoid excessive handling of suppository, which is designed to melt at body temperature.
Insert suppository completely into rectum with gentle pressure, pointed end first.
A small amount of lubricating gel may be used on the tip of the suppository to assist insertion.