Chlorzoxazone
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Questions & Answers
Side Effects & Adverse Reactions
Serious (including fatal) hepatocellular toxicity has been reported rarely in patients receiving chlorzoxazone. The mechanism is unknown but appears to be idiosyncratic and unpredictable. Factors predisposing patients to this rare event are not known. Patients should be instructed to report early signs and/or symptoms of hepatotoxicity such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, or jaundice. Chlorzoxazone should be discontinued immediately and a physician consulted if any of these signs or symptoms develop. Chlorzoxazone use should also be discontinued if a patient develops abnormal liver enzymes (e.g., AST, ALT, alkaline phosphatase and bilirubin.)
The concomitant use of alcohol or other central nervous system depressants may have an additive effect.
The safe use of chlorzoxazone has not been established with respect to the possible adverse effects upon fetal development. Therefore, it should be used in women of childbearing potential only when, in the judgement of the physician, the potential benefits outweigh the possible risks.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
Chlorzoxazone is indicated as an adjunct to rest, physical therapy, and other measures for the relief of discomfort associated with acute, painful musculoskeletal conditions. The mode of action of this drug has not been clearly identified, but may be related to its sedative properties. Chlorzoxazone does not directly relax tense skeletal muscles in man.
History
There is currently no drug history available for this drug.
Other Information
Chlorzoxazone USP is a centrally acting skeletal muscle relaxant, available as tablets of 500 mg for oral administration. Its chemical name is 5-Chloro-2-benzoxazolinone, and its structural formula is:
Chlorzoxazone Structural Formula
Chlorzoxazone Structural Formula
Chlorzoxazone Structural Formula
C7H4CINO2 MW 169.57
Chlorzoxazone USP is a white or practically white, practically odorless, crystalline powder. Chlorzoxazone is slightly soluble in water; sparingly soluble in alcohol, in isopropyl alcohol, and in methanol; soluble in solutions of alkali hydroxides and ammonia.
Chlorzoxazone tablets contain the inactive ingredients Docusate Sodium, Lactose (hydrous), Magnesium Stearate, Microcrystalline Cellulose, Pregelatinized Starch, Sodium Benzoate, and Sodium Starch Glycolate.
Sources
Chlorzoxazone Manufacturers
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Proficient Rx Lp
![Chlorzoxazone Tablet [Proficient Rx Lp]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Chlorzoxazone | Proficient Rx Lp
Usual Adult DosageOne tablet three or four times daily. If adequate response is not obtained with this dose, it may be increased to one and one-half tablets (750 mg) three or four times daily. As improvement occurs dosage can usually be reduced.
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Physicians Total Care, Inc.
Chlorzoxazone | Physicians Total Care, Inc.
Usual Adult DosageOne tablet three or four times daily. If adequate response is not obtained with this dose, it may be increased to one and one-half tablets (750 mg) three or four times daily. As improvement occurs dosage can usually be reduced.
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Dispensing Solutions, Inc.
Chlorzoxazone | Dispensing Solutions, Inc.
Usual Adult Dosage:One tablet three or four times daily. If adequate response is not obtained with this dose, it may be increased to 1½ tablets (750 mg) three or four times daily. As improvement occurs dosage can usually be reduced.
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Watson Laboratories, Inc.
Chlorzoxazone | Actavis Pharma, Inc.
Usual Adult DosageOne tablet three or four times daily. If adequate response is not obtained with this dose, it may be increased to one and one-half tablets (750 mg) three or four times daily. As improvement occurs dosage can usually be reduced.
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Stat Rx Usa Llc
Chlorzoxazone | Stat Rx Usa Llc
Usual Adult DosageOne tablet three or four times daily. If adequate response is not obtained with this dose, it may be increased to one and one-half tablets (750 mg) three or four times daily. As improvement occurs dosage can usually be reduced.
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Lake Erie Medical Dba Quality Care Products Llc
Chlorzoxazone | Lake Erie Medical Dba Quality Care Products Llc
Usual Adult DosageOne tablet three or four times daily. If adequate response is not obtained with this dose, it may be increased to one and one-half tablets (750 mg) three or four times daily. As improvement occurs dosage can usually be reduced.
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Rebel Distributors Corp
Chlorzoxazone | Rebel Distributors Corp
Usual Adult DosageOne tablet three or four times daily. If adequate response is not obtained with this dose, it may be increased to one and one half tablets (750 mg) three or four times daily. As improvement occurs dosage can usually be reduced.
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Unit Dose Services
Chlorzoxazone | Unit Dose Services
Usual Adult DosageOne tablet three or four times daily. If adequate response is not obtained with this dose, it may be increased to one and one-half tablets (750 mg) three or four times daily. As improvement occurs dosage can usually be reduced.
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Bryant Ranch Prepack
Chlorzoxazone | Bryant Ranch Prepack
Usual Adult DosageOne tablet three or four times daily. If adequate response is not obtained with this dose, it may be increased to one and one-half tablets (750 mg) three or four times daily. As improvement occurs dosage can usually be reduced.
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Rebel Distributors Corp
Chlorzoxazone | Rebel Distributors Corp
Usual Adult DosageOne tablet three or four times daily. If adequate response is not obtained with this dose, it may be increased to one and one-half tablets (750 mg) three or four times daily. As improvement occurs dosage can usually be reduced.
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Dispensing Solutions, Inc.
Chlorzoxazone | Dispensing Solutions, Inc.
Usual Adult DosageOne tablet three or four times daily. If adequate response is not obtained with this dose, it may be increased to one and one-half tablets (750 mg) three or four times daily. As improvement occurs dosage can usually be reduced.
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Clinical Solutions Wholesale
Chlorzoxazone | Clinical Solutions Wholesale
Usual Adult DosageOne tablet three or four times daily. If adequate response is not obtained with this dose, it may be increased to one and one-half tablets (750 mg) three or four times daily. As improvement occurs dosage can usually be reduced.
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A-s Medication Solutions Llc
Chlorzoxazone | A-s Medication Solutions Llc
Usual Adult DosageOne tablet three or four times daily. If adequate response is not obtained with this dose, it may be increased to one and one-half tablets (750 mg) three or four times daily. As improvement occurs dosage can usually be reduced.
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Aidarex Pharmaceuticals Llc
Chlorzoxazone | Aidarex Pharmaceuticals Llc
Usual Adult DosageOne tablet three or four times daily. If adequate response is not obtained with this dose, it may be increased to one and one-half tablets (750 mg) three or four times daily. As improvement occurs dosage can usually be reduced.
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Direct Rx
Chlorzoxazone | Direct Rx
Usual Adult Dosage
One tablet three or four times daily. If adequate response is not obtained with this dose, it may be increased to one and one-half tablets (750 mg) three or four times daily. As improvement occurs dosage can usually be reduced.
![Chlorzoxazone Tablet [Physicians Total Care, Inc.]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=650657fc-5655-41a4-974a-bc0e3a8317ab&name=0735.jpg)
![Chlorzoxazone Tablet [Dispensing Solutions, Inc.]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=3b91e3ba-1eb6-4297-9d1b-28d87b36a5b3&name=NDC55045-1594-08------BarrLaboratories,Inc.jpg)
![Chlorzoxazone Tablet [Watson Laboratories, Inc.]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=2f05e8e2-616f-475b-ac9f-c42e1a5dbe81&name=chlorzoxazone-tabs-new-ndc-2520-2.jpg)
![Chlorzoxazone Tablet [Stat Rx Usa Llc]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=ddd41f29-8c98-4fae-94e3-104a8e9365fc&name=CHLORZOXAZONE500MGLABEL.jpg)
![Chlorzoxazone Tablet [Lake Erie Medical Dba Quality Care Products Llc]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=fd11228a-0be9-4328-9527-ea41b2e1a22a&name=chlorzoxazone500mgteva.jpg)
![Chlorzoxazone Tablet [Rebel Distributors Corp]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=e1e1c8de-5658-4f94-bf20-f42b59b993c5&name=48945996-e8b9-462f-b454-3b11fd844a6d-02.jpg)
![Chlorzoxazone Tablet [Unit Dose Services]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=6d07e505-f5c6-412c-add5-5b5a7bab31e9&name=rspl50436-3444.jpg)
![Chlorzoxazone Tablet [Bryant Ranch Prepack]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=5e6889c9-a091-4622-0a00-ad0fc1830f78&name=label1datamaxfda416.jpg)
![Chlorzoxazone Tablet [Rebel Distributors Corp]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=9437b8ac-4f0e-4e5d-b699-23c492bf28ab&name=70cc0291-495b-4e2f-a431-ade9759ec4b7-02.jpg)
![Chlorzoxazone Tablet [Dispensing Solutions, Inc.]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=89aa488f-53a7-464b-80e7-13fbfdfd93b2&name=NDC66336-0663-XX------WATSON.jpg)
![Chlorzoxazone Tablet [Clinical Solutions Wholesale]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=3412520b-fa8a-4d3e-a999-75fe39294119&name=Chlor500Lab00.jpg)
![Chlorzoxazone Tablet [A-s Medication Solutions Llc]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=527ec3d3-4e48-403b-b1b2-cf33d343ccbb&name=1970-0.jpg)
![Chlorzoxazone Tablet [Aidarex Pharmaceuticals Llc]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=63f43b2a-dd5b-482c-a00c-7643d91c2292&name=chlorzoxazone-500mg-tabs-for-watson-2.jpg)
![Chlorzoxazone Tablet [Direct Rx]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=0ed64990-f2f2-40e9-be91-874f0a862f83&name=LABEL.jpg)
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