Clonidine

Clonidine Manufacturers

• Stat Rx Usa Llc
  

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  Clonidine | Stat Rx Usa Llc

  

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  DOSAGE AND ADMINISTRATION

  Adults: The dose of clonidine hydrochloride must be adjusted according to the patient’s individual blood pressure response. The following is a general guide to its administration.

  Initial Dose: 0.1 mg tablet twice daily (morning and bedtime). Elderly patients may benefit from a lower initial dose.

  Maintenance Dose: Further increments of 0.1 mg per day may be made at weekly intervals if necessary until the desired response is achieved. Taking the larger portion of the oral daily dose at bedtime may minimize transient adjustment effects of dry mouth and drowsiness. The therapeutic doses most commonly employed have ranged from 0.2 mg to 0.6 mg per day given in divided doses. Studies have indicated that 2.4 mg is the maximum effective daily dose, but doses as high as this have rarely been employed.

  Renal Impairment: Dosage must be adjusted according to the degree of impairment, and patients should be carefully monitored. Since only a minimal amount of clonidine is removed during routine hemodialysis, there is no need to give supplemental clonidine following dialysis.

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• Fresenius Kabi Usa, Llc
  

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  Clonidine | Fresenius Kabi Usa, Llc

  

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  The recommended starting dose of Clonidine Hydrochloride Injection for continuous epidural infusion is 30 mcg/hr.  Although dosage may be titrated up or down depending on pain relief and occurrence of adverse events, experience with dosage rates above 40 mcg/hr is limited. 

  Familiarization with the continuous epidural infusion device is essential.  Patients receiving epidural clonidine from a continuous infusion device should be closely monitored for the first few days to assess their response.

  The 500 mcg/mL (0.5 mg/mL) strength product must be diluted prior to use in 0.9% Sodium Chloride for Injection, USP, to a final concentration of 100 mcg/mL:

  
  

  Volume of Clonidine Hydrochloride Injection 500 mcg/mL

  Volume of 0.9%Sodium Chloride for Injection, USP

  
  

  Resulting Final Clonidine Hydrochloride Injection Concentration

  (100 mcg/mL)

  1 mL

  4 mL

  500 mcg/5 mL

  2 mL

  8 mL

  1000 mcg/10 mL

  3 mL

  12 mL

  1500 mcg/15 mL

  4 mL

  16 mL

  2000 mcg/20 mL

  5 mL

  20 mL

  2500 mcg/25 mL

  6 mL

  24 mL

  3000 mcg/30 mL

  7 mL

  28 mL

  3500 mcg/35 mL

  8 mL

  32 mL

  4000 mcg/40 mL

  9 mL

  36 mL

  4500 mcg/45 mL

  10 mL

  40 mL

  5000 mcg/50 mL

  Renal Impairment: Dosage should be adjusted according to the degree of renal impairment, and patients should be carefully monitored.  Since only a minimal amount of clonidine is removed during routine hemodialysis, there is no need to give supplemental clonidine following dialysis.

  Clonidine Hydrochloride Injection must not be used with a preservative.

  Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

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• X-gen Pharmaceuticals, Inc.
  

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  Clonidine | X-gen Pharmaceuticals, Inc.

  

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  The recommended starting dose of Clonidine Hydrochloride Injection for continuous epidural infusion is 30 mcg/hr.  Although dosage may be titrated up or down depending on pain relief and occurrence of adverse events, experience with dosage rates above 40 mcg/hr is limited. 

  Familiarization with the continuous epidural infusion device is essential.  Patients receiving epidural clonidine from a continuous infusion device should be closely monitored for the first few days to assess their response. 

  The 500 mcg/mL (0.5 mg/mL) strength product must be diluted prior to use in 0.9% Sodium Chloride for Injection, USP, to a final concentration of 100 mcg/mL:

  TABLE TWO Volume of Clonidine Hydrochloride Injection 500 mcg/mL  Volume of 0.9% Sodium Chloride for Injection, USP  Resulting Final Clonidine Hydrochloride Injection Concentration (100 mcg/mL)     1 mL    4 mL    500 mcg/5 mL    2 mL    8 mL  1000 mcg/10 mL    3 mL  12 mL  1500 mcg/15 mL    4 mL  16 mL  2000 mcg/20 mL    5 mL  20 mL  2500 mcg/25 mL    6 mL  24 mL  3000 mcg/30 mL    7 mL  28 mL  3500 mcg/35 mL    8 mL  32 mL  4000 mcg/40 mL    9 mL  36 mL  4500 mcg/45 mL  10 mL  40 mL  5000 mcg/50 mL

  Renal Impairment: Dosage should be adjusted according to the degree of renal impairment, and patients should be carefully monitored.  Since only a minimal amount of clonidine is removed during routine hemodialysis, there is no need to give supplemental clonidine following dialysis. 

  Clonidine Hydrochloride Injection must not be used with a preservative.

  Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.

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