Clonidine Hydrochloride

Clonidine Hydrochloride

Clonidine Hydrochloride Recall

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Questions & Answers

Side Effects & Adverse Reactions

Patients should be instructed not to discontinue therapy without consulting their physician. Sudden cessation of clonidine treatment has, in some cases, resulted in symptoms such as nervousness, agitation, headache, and tremor accompanied or followed by a rapid rise in blood pressure and elevated catecholamine concentrations in the plasma. The likelihood of such reactions to discontinuation of clonidine therapy appears to be greater after administration of higher doses or continuation of concomitant beta-blocker treatment and special caution is therefore advised in these situations. Rare instances of hypertensive encephalopathy, cerebrovascular accidents and death have been reported after clonidine withdrawal. When discontinuing therapy with clonidine hydrochloride tablets, the physician should reduce the dose gradually over 2 to 4 days to avoid withdrawal symptomatology.

An excessive rise in blood pressure following discontinuation of clonidine hydrochloride tablets therapy can be reversed by administration of oral clonidine hydrochloride or by intravenous phentolamine. If therapy is to be discontinued in patients receiving a beta-blocker and clonidine concurrently, the beta-blocker should be withdrawn several days before the gradual discontinuation of clonidine hydrochloride tablets.

Because children commonly have gastrointestinal illnesses that lead to vomiting, they may be particularly susceptible to hypertensive episodes resulting from abrupt inability to take medication.

 

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

Clonidine hydrochloride tablets, USP are indicated in the treatment of hypertension. Clonidine hydrochloride tablets, USP may be employed alone or concomitantly with other antihypertensive agents.

 

History

There is currently no drug history available for this drug.

Other Information

Clonidine hydrochloride, USP is a centrally acting alpha-agonist hypotensive agent available as tablets for oral administration in three dosage strengths: 0.1 mg, 0.2 mg and 0.3 mg. The 0.1 mg tablet is equivalent to 0.087 mg of the free base.

 

The inactive ingredients are dibasic calcium phosphate, FD&C Yellow #6 aluminum lake, lactose monohydrate, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, sodium starch glycolate. The clonidine hydrochloride 0.1 mg tablet also contains FD&C Blue #1 aluminum lake and FD&C Red #40 aluminum lake.

 

Clonidine hydrochloride is an imidazoline derivative and exists as a mesomeric compound. The chemical name is 2-(2,6-dichlorophenylamino)-2-imidazoline hydrochloride. The following is the structural formula:

MM1

Clonidine hydrochloride is an odorless, bitter, white, crystalline substance soluble in water and alcohol.

 

Clonidine Hydrochloride Manufacturers


  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Proficient Rx Lp
    Clonidine Hydrochloride Tablet [Proficient Rx Lp]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Preferred Pharmaceuticals, Inc.
    Clonidine Hydrochloride Tablet [Preferred Pharmaceuticals, Inc.]
  • Northwind Pharmaceuticals, Llc
    Clonidine Hydrochloride Tablet [Northwind Pharmaceuticals, Llc]
  • Proficient Rx Lp
    Clonidine Hydrochloride Tablet [Proficient Rx Lp]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • A-s Medication Solutions Llc
    Clonidine Hydrochloride Tablet [A-s Medication Solutions Llc]
  • A-s Medication Solutions Llc
    Clonidine Hydrochloride Tablet [A-s Medication Solutions Llc]
  • Direct Rx
    Clonidine Hydrochloride Tablet [Direct Rx]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Preferred Pharmaceuticals, Inc.
    Clonidine Hydrochloride Tablet [Preferred Pharmaceuticals, Inc.]
  • State Of Florida Doh Central Pharmacy
    Clonidine Hydrochloride Tablet [State Of Florida Doh Central Pharmacy]
  • Pharmaforce, Inc.
    Clonidine Hydrochloride Injection, Solution [Pharmaforce, Inc.]
  • State Of Florida Doh Central Pharmacy
    Clonidine Hydrochloride Tablet [State Of Florida Doh Central Pharmacy]
  • State Of Florida Doh Central Pharmacy
    Clonidine Hydrochloride Tablet [State Of Florida Doh Central Pharmacy]
  • State Of Florida Doh Central Pharmacy
    Clonidine Hydrochloride Tablet [State Of Florida Doh Central Pharmacy]
  • State Of Florida Doh Central Pharmacy
    Clonidine Hydrochloride Tablet [State Of Florida Doh Central Pharmacy]
  • Blenheim Pharmacal, Inc.
    Clonidine Hydrochloride Tablet [Blenheim Pharmacal, Inc.]
  • Contract Pharmacy Services-pa
    Clonidine Hydrochloride Tablet [Contract Pharmacy Services-pa]
  • Pd-rx Pharmaceuticals, Inc.
    Clonidine Hydrochloride Tablet [Pd-rx Pharmaceuticals, Inc.]
  • Lake Erie Medical Dba Quality Care Products Llc
    Clonidine Hydrochloride Tablet [Lake Erie Medical Dba Quality Care Products Llc]
  • Contract Pharmacy Services-pa
    Clonidine Hydrochloride Tablet [Contract Pharmacy Services-pa]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • West-ward Pharmaceutical Corp
    Clonidine Hydrochloride Injection, Solution [West-ward Pharmaceutical Corp]
  • Rebel Distributors Corp
    Clonidine Hydrochloride Tablet [Rebel Distributors Corp]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • St Marys Medical Park Pharmacy
    Clonidine Hydrochloride (Clonidine Hydrochloride) Tablet [St Marys Medical Park Pharmacy]
  • Dispensing Solutions, Inc.
    Clonidine Hydrochloride Tablet [Dispensing Solutions, Inc.]
  • Pd-rx Pharmaceuticals, Inc.
    Clonidine Hydrochloride Tablet [Pd-rx Pharmaceuticals, Inc.]
  • Pd-rx Pharmaceuticals, Inc.
    Clonidine Hydrochloride Tablet [Pd-rx Pharmaceuticals, Inc.]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Medvantx, Inc.
    Clonidine Hydrochloride Tablet [Medvantx, Inc.]
  • Pd-rx Pharmaceuticals, Inc.
    Clonidine Hydrochloride Tablet [Pd-rx Pharmaceuticals, Inc.]
  • Mckesson Contract Packaging
    Clonidine Hydrochloride Tablet [Mckesson Contract Packaging]
  • Unit Dose Services
    Clonidine Hydrochloride Tablet [Unit Dose Services]
  • Qualitest Pharmaceuticals
    Clonidine Hydrochloride Tablet [Qualitest Pharmaceuticals]
  • Lake Erie Medical & Surgical Supply Dba Quality Care Products Llc
    Clonidine Hydrochloride Tablet [Lake Erie Medical & Surgical Supply Dba Quality Care Products Llc]
  • Physicians Total Care, Inc.
    Clonidine Hydrochloride Tablet [Physicians Total Care, Inc.]
  • Dava Pharmaceuticals, Inc.
    Clonidine Hydrochloride Tablet [Dava Pharmaceuticals, Inc.]
  • Stat Rx Usa Llc
    Clonidine Hydrochloride Tablet [Stat Rx Usa Llc]
  • Bryant Ranch Prepack
    Clonidine Hydrochloride Tablet [Bryant Ranch Prepack]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Ncs Healthcare Of Ky, Inc Dba Vangard Labs
    Clonidine Hydrochloride Tablet [Ncs Healthcare Of Ky, Inc Dba Vangard Labs]
  • Remedyrepack Inc.
    Clonidine Hydrochloride (Clonidine Hydrochloride ) Tablet [Remedyrepack Inc. ]
  • Unit Dose Services
    Clonidine Hydrochloride Tablet [Unit Dose Services]
  • Unit Dose Services
    Clonidine Hydrochloride Tablet [Unit Dose Services]
  • Unichem Pharmaceuticals (Usa), Inc.
    Clonidine Hydrochloride Tablet [Unichem Pharmaceuticals (Usa), Inc.]
  • Med-health Pharma, Llc
    Clonidine Hydrochloride Tablet [Med-health Pharma, Llc]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Richmond Pharmaceuticals, Inc.
    Clonidine Hydrochloride Tablet [Richmond Pharmaceuticals, Inc.]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Mylan Institutional Inc.
    Clonidine Hydrochloride Tablet [Mylan Institutional Inc.]
  • American Health Packaging
    Clonidine Hydrochloride Tablet [American Health Packaging]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Preferred Pharmaceuticals, Inc
    Clonidine Hydrochloride Tablet [Preferred Pharmaceuticals, Inc]
  • A-s Medication Solutions Llc
    Clonidine Hydrochloride Tablet [A-s Medication Solutions Llc]
  • Lake Erie Medical Dba Quality Care Products Llc
    Clonidine Hydrochloride Tablet [Lake Erie Medical Dba Quality Care Products Llc]
  • Dispensing Solutions, Inc.
    Clonidine Hydrochloride Tablet [Dispensing Solutions, Inc.]
  • Lake Erie Medical Dba Quality Care Products Llc
    Clonidine Hydrochloride Tablet [Lake Erie Medical Dba Quality Care Products Llc]
  • Medvantx, Inc.
    Clonidine Hydrochloride Tablet [Medvantx, Inc.]
  • Actavis Elizabeth Llc
    Clonidine Hydrochloride Tablet [Actavis Elizabeth Llc]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Northstar Rxllc
    Clonidine Hydrochloride Tablet [Northstar Rxllc]
  • General Injectables & Vaccines, Inc
    Clonidine Hydrochloride (Clonidine Hydrochloride) Tablet [General Injectables & Vaccines, Inc]
  • Preferred Pharmaceuticals, Inc
    Clonidine Hydrochloride Tablet [Preferred Pharmaceuticals, Inc]
  • Preferred Pharmaceuticals, Inc
    Clonidine Hydrochloride Tablet [Preferred Pharmaceuticals, Inc]
  • Clinical Solutions Wholesale
    Clonidine Hydrochloride Tablet [Clinical Solutions Wholesale]
  • American Regent, Inc.
    Clonidine Hydrochloride Injection, Solution [American Regent, Inc.]
  • A-s Medication Solutions Llc
    Clonidine Hydrochloride Tablet [A-s Medication Solutions Llc]
  • Cardinal Health
    Clonidine Hydrochloride Tablet [Cardinal Health]
  • Apotheca, Inc
    Clonidine Hydrochloride Tablet [Apotheca, Inc]
  • Cardinal Health
    Clonidine Hydrochloride Tablet [Cardinal Health]
  • Major Pharmaceuticals
    Clonidine Hydrochloride Tablet [Major Pharmaceuticals]
  • Aidarex Pharmaceuticals Llc
    Clonidine Hydrochloride Tablet [Aidarex Pharmaceuticals Llc]
  • Aidarex Pharmaceuticals Llc
    Clonidine Hydrochloride Tablet [Aidarex Pharmaceuticals Llc]
  • Mckesson Packaging Services A Business Unit Of Mckesson Corporation
    Clonidine Hydrochloride Tablet [Mckesson Packaging Services A Business Unit Of Mckesson Corporation]
  • Pd-rx Pharmaceuticals, Inc.
    Clonidine Hydrochloride Tablet [Pd-rx Pharmaceuticals, Inc.]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Bluepoint Laboratories
    Clonidine Hydrochloride Tablet [Bluepoint Laboratories]
  • State Of Florida Doh Central Pharmacy
    Clonidine Hydrochloride Tablet [State Of Florida Doh Central Pharmacy]
  • Cardinal Health
    Clonidine Hydrochloride Tablet [Cardinal Health]
  • Cardinal Health
    Clonidine Hydrochloride Tablet [Cardinal Health]
  • Carlsbad Technology, Inc
    Clonidine Hydrochloride Tablet [Carlsbad Technology, Inc]
  • Mylan Pharmaceuticals Inc.
    Clonidine Hydrochloride Tablet [Mylan Pharmaceuticals Inc.]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Bryant Ranch Prepack
    Clonidine Hydrochloride Tablet [Bryant Ranch Prepack]
  • Bryant Ranch Prepack
    Clonidine Hydrochloride Tablet [Bryant Ranch Prepack]
  • Tya Pharmaceuticals
    Clonidine Hydrochloride Tablet [Tya Pharmaceuticals]
  • Cardinal Health
    Clonidine Hydrochloride Tablet [Cardinal Health]
  • Tya Pharmaceuticals
    Clonidine Hydrochloride Tablet [Tya Pharmaceuticals]
  • Mutual Pharmaceutical Company, Inc.
    Clonidine Hydrochloride Tablet [Mutual Pharmaceutical Company, Inc.]
  • Northwind Pharmaceuticals, Llc
    Clonidine Hydrochloride Tablet [Northwind Pharmaceuticals, Llc]
  • St Marys Medical Park Pharmacy
    Clonidine Hydrochloride Tablet [St Marys Medical Park Pharmacy]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]
  • Clinical Solutions Wholesale, Llc
    Clonidine Hydrochloride Tablet [Clinical Solutions Wholesale, Llc]
  • American Health Packaging
    Clonidine Hydrochloride Tablet [American Health Packaging]
  • Remedyrepack Inc.
    Clonidine Hydrochloride Tablet [Remedyrepack Inc. ]

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