Clopidogrel

Clopidogrel

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Questions & Answers

Side Effects & Adverse Reactions

There is currently no warning information available for this product. We apologize for any inconvenience.

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

1.1 Acute Coronary Syndrome (ACS) • For patients with non-ST-segment elevation ACS [unstable angina (UA)/non-ST-elevation myocardial infarction (NSTEMI)], including patients who are to be managed medically and those who are to be managed with coronary revascularization, clopidogrel bisulfate has been shown to decrease the rate of a combined endpoint of cardiovascular death, myocardial infarction (MI), or stroke as well as the rate of a combined endpoint of cardiovascular death, MI, stroke, or refractory ischemia. • For patients with ST-elevation myocardial infarction (STEMI), clopidogrel bisulfate has been shown to reduce the rate of death from any cause and the rate of a combined endpoint of death, re-infarction, or stroke. The benefit for patients who undergo primary percutaneous coronary intervention is unknown.

The optimal duration of clopidogrel bisulfate therapy in ACS is unknown.

1.2 Recent MI, Recent Stroke, or Established Peripheral Arterial Disease

For patients with a history of recent myocardial infarction (MI), recent stroke, or established peripheral arterial disease, clopidogrel bisulfate has been shown to reduce the rate of a combined endpoint of new ischemic stroke (fatal or not), new MI (fatal or not), and other vascular death.

History

There is currently no drug history available for this drug.

Other Information

Clopidogrel bisulfate is an inhibitor of ADP-induced platelet aggregation acting by direct inhibition of adenosine diphosphate (ADP) binding to its receptor and of the subsequent ADP-mediated activation of the glycoprotein GPIIb/IIIa complex. Chemically it is methyl (+)-(S)-α-(2-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetate sulfate (1:1). The empirical formula of clopidogrel bisulfate is C16H16ClNO2S•H2SO4 and its molecular weight is 419.9. 

The structural formula is as follows:

clopiodgrel-01

Clopidogrel bisulfate is a white to off-white powder. It is practically insoluble in water at neutral pH but freely soluble at pH 1. It also dissolves freely in methanol, dissolves sparingly in methylene chloride, and is practically insoluble in ethyl ether. It has a specific optical rotation of about +56°.

Clopidogrel tablets, USP 75 mg for oral administration are provided as pink, round, biconvex, film coated tablets, engraved “APO” on one side, “CL” over “75” on the other side. The tablets contain 97.875 mg of clopidogrel bisulfate, which is the molar equivalent of 75 mg of clopidogrel base.

Each tablet contains anhydrous lactose, colloidal silicon dioxide, crospovidone, methylcellulose and zinc stearate as inactive ingredients. The pink film coating contains hydroxypropyl cellulose, hypromellose, polyethylene glycol, red ferric oxide and titanium dioxide.

Clopidogrel Manufacturers


  • Cardinal Health
    Clopidogrel (Clopidogrel Bisulfate) Tablet, Film Coated [Cardinal Health]
  • Remedyrepack Inc.
    Clopidogrel Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Clopidogrel Tablet [Remedyrepack Inc. ]
  • Major Pharmaceuticals
    Clopidogrel (Clopidogrel Bisulfate) Tablet, Film Coated [Major Pharmaceuticals]
  • Direct Rx
    Clopidogrel Tablet, Film Coated [Direct Rx]
  • State Of Florida Doh Central Pharmacy
    Clopidogrel (Clopidogrel Bisulphate) Tablet, Film Coated [State Of Florida Doh Central Pharmacy]
  • State Of Florida Doh Central Pharmacy
    Clopidogrel Tablet, Film Coated [State Of Florida Doh Central Pharmacy]
  • Remedyrepack Inc.
    Clopidogrel (Clopidogrel Bisulfate) Tablet, Film Coated [Remedyrepack Inc. ]
  • Vensun Pharmaceuticals, Inc.
    Clopidogrel Tablet [Vensun Pharmaceuticals, Inc.]
  • American Health Packaging
    Clopidogrel (Clopidogrel Bisulfate) Tablet, Film Coated [American Health Packaging]
  • Legacy Pharmaceutical Packaging
    Clopidogrel Tablet, Film Coated [Legacy Pharmaceutical Packaging]
  • Wockhardt Usa Llc.
    Clopidogrel Tablet, Film Coated [Wockhardt Usa Llc.]
  • Wockhardt Limited
    Clopidogrel Tablet, Film Coated [Wockhardt Limited]
  • American Health Packaging
    Clopidogrel Tablet, Film Coated [American Health Packaging]
  • Unit Dose Services
    Clopidogrel (Clopidogrel Bisulfate) Tablet, Film Coated [Unit Dose Services]
  • Remedyrepack Inc.
    Clopidogrel (Clopidogrel Bisulfate ) Tablet, Film Coated [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Clopidogrel (Clopidogrel Bisulfate ) Tablet, Film Coated [Remedyrepack Inc. ]
  • Medvantx, Inc.
    Clopidogrel Tablet, Film Coated [Medvantx, Inc.]
  • Aidarex Pharmaceuticals Llc
    Clopidogrel (Clopidogrel Bisulfate) Tablet, Film Coated [Aidarex Pharmaceuticals Llc]
  • Teva Pharmaceuticals Usa Inc
    Clopidogrel Tablet, Film Coated [Teva Pharmaceuticals Usa Inc]
  • Aurobindo Pharma Limited
    Clopidogrel (Clopidogrel Bisulfate) Tablet, Film Coated [Aurobindo Pharma Limited]
  • Macleods Pharmaceuticals Limited
    Clopidogrel Tablet [Macleods Pharmaceuticals Limited]
  • American Health Packaging
    Clopidogrel (Clopidogrel Bisulfate) Tablet, Film Coated [American Health Packaging]
  • Accord Healthcare Inc.
    Clopidogrel (Clopidogrel Bisulphate) Tablet, Film Coated [Accord Healthcare Inc.]
  • State Of Florida Doh Central Pharmacy
    Clopidogrel (Clopidogrel Bisulfate ) Tablet, Film Coated [State Of Florida Doh Central Pharmacy]
  • Legacy Pharmaceutical Packaging
    Clopidogrel Tablet, Film Coated [Legacy Pharmaceutical Packaging]
  • Amneal Pharmaceuticals Of New York, Llc
    Clopidogrel Tablet [Amneal Pharmaceuticals Of New York, Llc]
  • Readymeds
    Clopidogrel (Clopidogrel Bisulfate) Tablet, Film Coated [Readymeds]
  • Bryant Ranch Prepack
    Clopidogrel Tablet, Film Coated [Bryant Ranch Prepack]
  • Ncs Healthcare Of Ky, Inc Dba Vangard Labs
    Clopidogrel Tablet, Film Coated [Ncs Healthcare Of Ky, Inc Dba Vangard Labs]
  • International Labs, Inc.
    Clopidogrel Tablet, Film Coated [International Labs, Inc.]
  • Clinical Solutions Wholesale
    Clopidogrel (Clopidogrel Bisulfate) Tablet, Film Coated [Clinical Solutions Wholesale]
  • Apotex Corp.
    Clopidogrel (Clopidogrel Bisulfate) Tablet, Film Coated [Apotex Corp.]
  • St Marys Medical Park Pharmacy
    Clopidogrel Tablet, Film Coated [St Marys Medical Park Pharmacy]

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