The dosage for adults and adolescents older than 16 years of age is 0.6 mg (one tablet) once or twice daily. Maximum dose 1.2 mg/day.
Dosage reduction should be carefully considered in patients with impaired hepatic or renal function and in patients who are receiving concomitant treatment with P-gp and CYP3A4 inhibitors.
Colchicine tablets are administered orally, without regard to meals.
Colchicine is not an analgesic medication and should not be used to treat pain from other causes.
The safety and efficacy of colchicine in children to reduce the incidence of acute gout flares has not been evaluated.