Eliquis

Eliquis Manufacturers

• Cardinal Health
  

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  Eliquis | Maywell Co., Ltd.

  

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  Dosage & Administration: Five times in the face, neck three times

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• E.r. Squibb & Sons, L.l.c.
  

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  Eliquis | Clinical Solutions Wholesale

  

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  Acute Treatment of Herpes Zoster

  800 mg every 4 hours orally, 5 times daily for 7 to 10 days.

  Genital Herpes Treatment of Initial Genital Herpes

  200 mg every 4 hours, 5 times daily for 10 days.

  Chronic Suppressive Therapy for Recurrent Disease

  400 mg 2 times daily for up to 12 months, followed by re-evaluation. Alternative regimens have included doses ranging from 200 mg 3 times daily to 200 mg 5 times daily.

  The frequency and severity of episodes of untreated genital herpes may change over time. After 1 year of therapy, the frequency and severity of the patient’s genital herpes infection should be re-evaluated to assess the need for continuation of therapy with acyclovir.

  Intermittent Therapy

  200 mg every 4 hours, 5 times daily for 5 days. Therapy should be initiated at the earliest sign or symptom (prodrome) of recurrence.

  Treatment of Chickenpox Children (2 Years of age and Older)

  20 mg/kg per dose orally 4 times daily (80 mg/kg/day) for 5 days. Children over 40 kg should receive the adult dose for chickenpox.

  Adults and Children Over 40 kg

  800 mg 4 times daily for 5 days.

  Intravenous acyclovir is indicated for the treatment of varicella-zoster infections in immunocompromised patients.

  When therapy is indicated, it should be initiated at the earliest sign or symptom of chickenpox. There is no information about the efficacy of therapy initiated more than 24 hours after onset of signs and symptoms.

  Patients With Acute or Chronic Renal Impairment

  In patients with renal impairment, the dose of acyclovir capsules and tablets should be modified as shown in Table 3:

  Table 3: Dosage Modification for Renal Impairment

  Normal Dosage Regimen

  Creatinine Clearance (mL/min/1.73 m 2)

  Adjusted Dosage Regimen

  Dose (mg)

  Dosing Interval

  200 mg every 4 hours

  > 10

  200

  every 4 hours, 5x daily

  0 to 10

  200

  every 12 hours

  400 mg every 12 hours

  > 10

  400

  every 12 hours

  0 to 10

  200

  every 12 hours

  800 mg every 4 hours

  > 25

  800

  every 4 hours, 5x daily

  10 to 25

  800

  every 8 hours

  0 to 10

  800

  every 12 hours

  Hemodialysis

  For patients who require hemodialysis, the mean plasma half-life of acyclovir during hemodialysis is approximately 5 hours. This results in a 60% decrease in plasma concentrations following a 6 hour dialysis period. Therefore, the patient’s dosing schedule should be adjusted so that an additional dose is administered after each dialysis.

  Peritoneal Dialysis

  No supplemental dose appears to be necessary after adjustment of the dosing interval.

  Bioequivalence of Dosage Forms

  Acyclovir suspension was shown to be bioequivalent to acyclovir capsules (n = 20) and 1 acyclovir 800 mg tablet was shown to be bioequivalent to 4 acyclovir 200 mg capsules (n = 24).

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