The recommended Adenosine Injection dose is 0.14 mg/kg/min infused over six minutes (total dose of 0.84 mg/kg) (Table 1).
Administer adenosine only as a continuous peripheral intravenous infusion
Inject Thallium-201 at the midpoint of the adenosine infusion (i.e., after the first three minutes of adenosine)
Thallium-201 is physically compatible with adenosine and may be injected directly into the adenosine infusion set
Inject Thallium-201 as close to the venous access as possible to prevent an inadvertent increase in the dose of adenosine (the contents of the intravenous tubing) being administered
Visually inspect adenosine for particulate matter and discoloration prior to administration. Do not administer adenosine if it contains particulate matter or is discolored.
There are no data on the safety or efficacy of alternative adenosine infusion protocols. The safety and efficacy of adenosine administered by the intracoronary route have not been established.
Table 1 Dosage Chart for Adenosine Injection
Patient Weight
(kilograms)
Infusion Rate
(mL per minute over 6 minutes for total dose of
0.84 mg/kg)
45
2.1
50
2.3
55
2.6
60
2.8
65
3
70
3.3
75
3.5
80
3.8
85
4
90
4.2
The nomogram displayed in Table 1 was derived from the following general formula:
0.14 (mg/kg/min) x
total body weight (kg) = Infusion rate
Adenosine concentration (mL/min)
(3 mg/mL)