Use morning and evening after washing two times mostly Because makeup base is possible with these serum and cream, makeup for other moisturizing products does not need. The serum used first and then using the cream. Apply serum in face and serum tap lightly with palm until is absorbed in skin. Apply cream in face and massage lightly with palm until cream is assimilated in skin. Use is possible to atopic sensitive skin or young infant because composition antiseptic of minimum quantity was contained to serum and there is no composition antiseptic to cream