Incurin
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Questions & Answers
Side Effects & Adverse Reactions
Not for human use. Keep out of the reach of children. Women who are of child-bearing age or those who are breastfeeding should use caution when administering INCURIN™ Tablets. Wash your hands with soap and water after administration to avoid exposure to the drug. Consult a physician in case of accidental ingestion by humans.
Some estrogens have been associated with bone marrow changes and an increased risk of mammary tumors. However, target animal safety study results and foreign post-market pharmacovigilance data for INCURIN™ Tablets have shown that estriol-treated dogs are at low risk for developing these conditions.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
INCURIN™ Tablets are indicated for the control of estrogen-responsive urinary incontinence in ovariohysterectomized female dogs.
History
There is currently no drug history available for this drug.
Other Information
INCURIN™ (estriol) Tablets contain 1 mg of estriol per tablet.
USP Chemical Name: Estra-1,3,5(10)-triene-3,16,17-triol, (16α,17β)-.
USP Molecular Weight: 288.38
USP Solubility: Soluble in acetone, in chloroform, in dioxane, in ether, and in vegetable oils; sparingly soluble in alcohol; insoluble in water.
Sources
Incurin Manufacturers
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Merck Sharp & Dohme Corp.
![Incurin (Estriol) Tablet [Merck Sharp & Dohme Corp.]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Incurin | Merck Sharp & Dohme Corp.
The dose of INCURIN™ Tablets is not dependent upon body weight. All dogs should receive an initial dose of 2 mg INCURIN™ Tablets (2 tablets) orally once per day for a minimum of 14 days. After urinary incontinence is controlled, the lowest effective daily dose of INCURIN™ Tablets should be determined by decreasing the dose in a step-wise manner from 2 mg once daily (2 tablets) to 1 mg once daily (1 tablet), then 0.5 mg once daily (1/2 tablet) depending upon the response of the individual dog. There should be a minimum of 7 days between each dose adjustment. After the lowest daily dose that controls urinary incontinence is identified, the dose may be decreased further by administering once every two days. Dogs should not receive more than 2 mg INCURIN™ Tablets per day (2 tablets). If the dog does not respond to 2 mg of INCURIN™ Tablets per day, the diagnosis should be re-assessed.
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