Isosorbide Mononitrate

Isosorbide Mononitrate

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Questions & Answers

Side Effects & Adverse Reactions

Amplification of the vasodilatory effects of isosorbide mononitrate by sildenafil can result in severe hypotension. The time course and dose dependence of this interaction have not been studied. Appropriate supportive care has not been studied, but it seems reasonable to treat this as a nitrate overdose, with elevation of the extremities and with central volume expansion.

The benefits of ISMN in patients with acute myocardial infarction or congestive heart failure have not been established; because the effects of isosorbide mononitrate are difficult to terminate rapidly, this drug is not recommended in these settings.

If isosorbide mononitrate is used in these conditions, careful clinical or hemodynamic monitoring must be used to avoid the hazards of hypotension and tachycardia.

 

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

Isosorbide Mononitrate Extended-Release Tablets are indicated for the prevention of angina pectoris due to coronary artery disease. The onset of action of oral isosorbide mononitrate is not sufficiently rapid for this product to be useful in aborting an acute anginal episode.

 

History

There is currently no drug history available for this drug.

Other Information

Isosorbide mononitrate (ISMN), an organic nitrate and the major biologically active metabolite of isosorbide dinitrate (ISDN), is a vasodilator with effects on both arteries and veins.

Each tablet, for oral administration, contains either 30 mg, 60 mg or 120 mg of isosorbide mononitrate in an extended-release formulation. In addition, each tablet contains the following inactive ingredients: colloidal silicon dioxide, hydrogenated castor oil, hypromellose, lactose monohydrate, magnesium stearate, microcrystalline cellulose and talc.

The molecular formula of ISMN is C6H9NO6 and the molecular weight is 191.14. The chemical name for ISMN is 1,4:3,6-dianhydro-,D-glucitol 5-nitrate; the compound has the following structural formula:

MM1

ISMN is a white, crystalline, odorless compound which is stable in air and in solution, has a melting point of about 90°C, and an optical rotation of +144° (2% in water, 20°C).

Isosorbide mononitrate is freely soluble in water, ethanol, methanol, chloroform, ethyl acetate, and dichloromethane.

 

Isosorbide Mononitrate Manufacturers


  • Remedyrepack Inc.
    Isosorbide Mononitrate Tablet, Extended Release [Remedyrepack Inc. ]
  • Lake Erie Medical Dba Quality Care Products Llc
    Isosorbide Mononitrate Tablet, Extended Release [Lake Erie Medical Dba Quality Care Products Llc]
  • Blenheim Pharmacal, Inc.
    Isosorbide Mononitrate Tablet, Extended Release [Blenheim Pharmacal, Inc.]
  • Cardinal Health
    Isosorbide Mononitrate Tablet, Extended Release [Cardinal Health]
  • Rebel Distributors Corp
    Isosorbide Mononitrate Tablet, Extended Release [Rebel Distributors Corp]
  • Rebel Distributors Corp
    Isosorbide Mononitrate Tablet, Extended Release [Rebel Distributors Corp]
  • Torrent Pharmaceuticals Limited
    Isosorbide Mononitrate Tablet, Extended Release [Torrent Pharmaceuticals Limited]
  • Pd-rx Pharmaceuticals, Inc.
    Isosorbide Mononitrate Tablet, Extended Release [Pd-rx Pharmaceuticals, Inc.]
  • Kremers Urban Pharmaceuticals Inc.
    Isosorbide Mononitrate Tablet [Kremers Urban Pharmaceuticals Inc.]
  • Ncs Healthcare Of Ky, Inc Dba Vangard Labs
    Isosorbide Mononitrate Tablet [Ncs Healthcare Of Ky, Inc Dba Vangard Labs]
  • Physicians Total Care, Inc.
    Isosorbide Mononitrate Tablet, Extended Release [Physicians Total Care, Inc.]
  • Mckesson Contract Packaging
    Isosorbide Mononitrate Tablet, Film Coated, Extended Release [Mckesson Contract Packaging]
  • Kremers Urban Pharmaceuticals Inc.
    Isosorbide Mononitrate Tablet, Extended Release [Kremers Urban Pharmaceuticals Inc.]
  • Physicians Total Care, Inc.
    Isosorbide Mononitrate Tablet [Physicians Total Care, Inc.]
  • Qualitest Pharmaceuticals
    Isosorbide Mononitrate Tablet, Extended Release [Qualitest Pharmaceuticals]
  • Ncs Healthcare Of Ky, Inc Dba Vangard Labs
    Isosorbide Mononitrate Tablet, Film Coated, Extended Release [Ncs Healthcare Of Ky, Inc Dba Vangard Labs]
  • Bryant Ranch Prepack
    Isosorbide Mononitrate Tablet, Extended Release [Bryant Ranch Prepack]
  • Bryant Ranch Prepack
    Isosorbide Mononitrate Tablet, Extended Release [Bryant Ranch Prepack]
  • Remedyrepack Inc.
    Isosorbide Mononitrate Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Isosorbide Mononitrate Tablet, Extended Release [Remedyrepack Inc. ]
  • Mckesson Contract Packaging
    Isosorbide Mononitrate Tablet, Extended Release [Mckesson Contract Packaging]
  • Ncs Healthcare Of Ky, Inc Dba Vangard Labs
    Isosorbide Mononitrate Tablet, Extended Release [Ncs Healthcare Of Ky, Inc Dba Vangard Labs]
  • St Marys Medical Park Pharmacy
    Isosorbide Mononitrate Tablet, Extended Release [St Marys Medical Park Pharmacy]
  • Cardinal Health
    Isosorbide Mononitrate Tablet, Extended Release [Cardinal Health]
  • Remedyrepack Inc.
    Isosorbide Mononitrate Tablet, Extended Release [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Isosorbide Mononitrate Tablet, Extended Release [Remedyrepack Inc. ]
  • Mckesson Contract Packaging
    Isosorbide Mononitrate Tablet, Extended Release [Mckesson Contract Packaging]
  • Remedyrepack Inc.
    Isosorbide Mononitrate Tablet, Extended Release [Remedyrepack Inc. ]
  • American Health Packaging
    Isosorbide Mononitrate Tablet, Film Coated, Extended Release [American Health Packaging]
  • Lake Erie Medical Dba Quality Care Products Llc
    Isosorbide Mononitrate Tablet, Extended Release [Lake Erie Medical Dba Quality Care Products Llc]
  • Lake Erie Medical Dba Quality Care Products Llc
    Isosorbide Mononitrate Tablet, Extended Release [Lake Erie Medical Dba Quality Care Products Llc]
  • Actavis Elizabeth Llc
    Isosorbide Mononitrate Tablet [Actavis Elizabeth Llc]
  • Ncs Healthcare Of Ky, Inc Dba Vangard Labs
    Isosorbide Mononitrate Tablet, Extended Release [Ncs Healthcare Of Ky, Inc Dba Vangard Labs]
  • Remedyrepack Inc.
    Isosorbide Mononitrate Tablet, Extended Release [Remedyrepack Inc. ]
  • Unit Dose Services
    Isosorbide Mononitrate Tablet, Extended Release [Unit Dose Services]
  • Unit Dose Services
    Isosorbide Mononitrate Tablet, Extended Release [Unit Dose Services]
  • Zydus Pharmaceuticals (Usa) Inc.
    Isosorbide Mononitrate Tablet [Zydus Pharmaceuticals (Usa) Inc.]
  • American Health Packaging
    Isosorbide Mononitrate Tablet, Extended Release [American Health Packaging]
  • Aphena Pharma Solutions – Tennessee, Llc
    Isosorbide Mononitrate Tablet, Extended Release [Aphena Pharma Solutions – Tennessee, Llc]
  • Cardinal Health
    Isosorbide Mononitrate Tablet, Extended Release [Cardinal Health]
  • Carilion Materials Management
    Isosorbide Mononitrate Tablet [Carilion Materials Management]
  • Aphena Pharma Solutions – Tennessee, Llc
    Isosorbide Mononitrate Tablet, Extended Release [Aphena Pharma Solutions – Tennessee, Llc]
  • Aphena Pharma Solutions – Tennessee, Llc
    Isosorbide Mononitrate Tablet, Extended Release [Aphena Pharma Solutions – Tennessee, Llc]
  • Cardinal Health
    Isosorbide Mononitrate Tablet, Extended Release [Cardinal Health]
  • Heritage Pharmaceuticals Inc.
    Isosorbide Mononitrate Tablet, Extended Release [Heritage Pharmaceuticals Inc.]
  • Avpak
    Isosorbide Mononitrate (Isosorbide Mononitrate) Tablet, Extended Release [Avpak]

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