2.1 Preoperative Prophylactic Use in Adults
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Only use Cefazolin injection in patients who require the entire 2 gram dose and not any fraction of it.
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Administer the entire 2 gram dose intravenously 1/2 hour to 1 hour prior to the start of surgery.
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It is important that the preoperative dose be given just prior (1/2 hour to 1 hour) to the start of surgery so that adequate antibacterial concentrations are present in the serum and tissues at the time of initial surgical incision.
2.2 Patients with Renal Impairment
Use Cefazolin injection only in patients whose creatinine clearance is greater than or equal to 35 mL/min and require the entire 2 gram dose and not any fraction of it.
2.3 Important Administration Instructions
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This premixed solution is for intravenous use only.
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Administer Cefazolin injection intravenously over approximately 30 minutes.
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Do not use plastic containers in series connections. Such use would result in air embolism due to residual air being drawn from the primary container before administration of the fluid from the secondary container is complete. If administration is controlled by a pumping device, care must be taken to discontinue pumping action before the container runs dry or air embolism may result.
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Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration. Use only if solution is clear and container and seals are intact.
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Do not introduce additives into the GALAXY Container.
2.4 Directions for Use of Cefazolin Injection
Thawing of Plastic Container
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Thaw frozen container at room temperature (25°C/ 77°F) or under refrigeration (5°C/41°F). Product should not be thawed by immersion in water baths or by microwave irradiation. Do not force thaw.
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No further dilution is necessary.
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Check for minute leaks by squeezing container firmly. If leaks are detected, discard solution as sterility may be impaired.
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Do not add supplementary medication.
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The container should be visually inspected. If the outlet port protector is damaged, detached, or not present, discard container as solution path sterility may be impaired. Components of the solution may precipitate in the frozen state and will dissolve upon reaching room temperature with little or no agitation. Potency is not affected. Agitate after solution has reached room temperature. If after visual inspection the solution remains cloudy or if an insoluble precipitate is noted or if any seals are not intact, the container should be discarded.
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The thawed solution is stable for 30 days under refrigeration (5°C/41°F) and 48 hours at 25°C/77°F.
Do not refreeze thawed antibacterial drugs.
Preparation for Administration
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Suspend container from support.
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Remove protector from outlet port at bottom of container.
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Attach Intravenous administration set to outlet port. Refer to the manufacturer’s instructions accompanying the administration set for complete directions.