Levetiracetam Extended-release

Levetiracetam Extended-release Manufacturers

• Anchen Pharmaceuticals, Inc.
  

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  Levetiracetam Extended-release | Anchen Pharmaceuticals, Inc.

  

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  Treatment should be initiated with a dose of 1000 mg once daily. The daily dosage may be adjusted in increments of 1000 mg every 2 weeks to a maximum recommended daily dose of 3000 mg.

  2.1 Adult Patients With Impaired Renal Function

  Extended-release levetiracetam tablets dosing must be individualized according to the patient’s renal function status. Recommended doses and adjustment for dose for adults are shown in Table 1. To use this dosing table, an estimate of the patient’s creatinine clearance (CLcr) in mL/min is needed. CLcr in mL/min may be estimated from serum creatinine (mg/dL) determination using the following formula:

  Table 1: Dosing Adjustment Regimen For Adult Patients With Impaired Renal Function Group Creatinine
  Clearance
  (mL/min/1.73m2) Dosage
  (mg) Frequency Normal > 80 1000 to
  3000 Every 24 h Mild 50 to 80 1000 to
  2000 Every 24 h Moderate 30 to 50 500 to 1500 Every 24 h Severe < 30 500 to 1000 Every 24 h

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• Golden State Medical Supply, Inc.
  

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  Levetiracetam Extended-release | Golden State Medical Supply, Inc.

  

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  Levetiracetam extended-release tablet is administered once daily.

  Treatment should be initiated with a dose of 1,000 mg once daily. The once daily dosage may be adjusted in increments of 1,000 mg every 2 weeks to a maximum recommended once daily dose of 3,000 mg.

  2.1 Adult Patients with Impaired Renal Function

  Levetiracetam extended-release tablets dosing must be individualized according to the patient's renal function status. Recommended doses and adjustment for dose for adults are shown in Table 1. In order to calculate the dose recommended for patients with renal impairment, creatinine clearance adjusted for body surface area must be calculated. To do this, an estimate of the patient's creatinine clearance (CLcr) in mL/min must first be calculated using the following formula:

                   [140-age (years)] x weight (kg)
  CLcr =   ----------------------------------------------   (x 0.85 for female patients)
                   72 x serum creatinine (mg/dL)
  

  Then CLcr is adjusted for body surface area (BSA) as follows:

                                                   CLcr (mL/min)
  CLcr (mL/min/1.73m2) =    -----------------------------    x 1.73
                                                 BSA subject (m2)

  Table 1: Dosing Adjustment Regimen For Adult Patients With Impaired Renal Function

  Group

  Creatinine
  Clearance
  (mL/min/1.73m2

  Dosage 
  (mg)

  Frequency

  Normal

  > 80

  1,000 to 3,000

  Every 24 hours

  Mild

  50 to 80

  1,000 to 2,000

  Every 24 hours

  Moderate

  30 to 50

  500 to 1,500

  Every 24 hours

  Severe

  < 30

  500 to 1,000

  Every 24 hours

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