WARNINGS: Caution is recommended in patients with a history of bipolar illness. Mood elevation is possible in this population.
Caution is also recommended in patients taking anticonvulsant medications as folate may interfere with anticonvulsant medication, and may lower seizure threshold. Furthermore, it has been reported that anticonvulsant medications interfere with folate metabolism, but the exact action is unclear; therefore caution is recommended with patients in this therapeutic group.
Folinic acid may enhance the toxicity of fluorouracil. Deaths from severe enterocolitis, diarrhea, and dehydration have been reported in elderly patients receiving weekly formyl-THF and fluorouracil. Concomitant granulocytopenia and fever were present in some but not all of the patients. The concomitant use of formyl-THF with trimethoprim-sulfamethoxazole for the acute treatment of Pneumocystis carinii pneumonia in patients with HIV infection was associated with increased rates of treatment failure and mortality in a placebo controlled study.13
Patients undergoing cancer treatment should consult their licensed medical practitioner for advice.
INDICATIONS AND USAGE: Cyanocobalamin/Levomefolate Calcium/Pyridoxine HCl (2 mg-1.13 mg-25 mg) is indicated for the distinct nutritional requirements of patients in need of advanced folate supplementation-specifically suboptimal folate or maintenance-level needs, as determined by a licensed medical practitioner. Cyanocobalamin/Levomefolate Calcium/Pyridoxine HCl (2 mg-1.13 mg-25 mg) should be administered under the supervision of a licensed medical practitioner.
DESCRIPTION: Cyanocobalamin/Levomefolate Calcium/Pyridoxine HCl (2 mg-1.13 mg-25 mg) is an orally administered prescription dietary supplement specifically formulated for the dietary management of patients with unique nutritional needs requiring increased folate levels.
Cyanocobalamin/Levomefolate Calcium/Pyridoxine HCl (2 mg-1.13 mg-25 mg) should be administered under the supervision of a licensed medical practitioner.
Each orange, tablet contains the following dietary ingredients:
*
contains less than 1% d-methylfolate.
†
Daily Value not established for patients with unique nutritional needs who are in need of supplementation as directed by a licensed medical practitioner.
DOSAGE AND ADMINISTRATION: Usual adult dose is one caplet daily or as prescribed by a licensed medical practitioner. Levomefolate Calcium/Acetylcysteine/Mecobalamin/Algal Powder (6 mg-600 mg-2 mg-90.314 mg) is not recommended for use in children under the age of twelve.