Mebendazole
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Questions & Answers
Side Effects & Adverse Reactions
There is no evidence that mebendazole, even at high doses, is effective for hydatid disease. There have been rare reports of neutropenia and agranulocytosis when mebendazole was taken for prolonged periods and at dosages substantially above those recommended.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
Mebendazole tablets are indicated for the treatment of Enterobius vermicularis (pinworm), Trichuris trichiura (whipworm), Ascaris lumbricoides (common roundworm), Ancylostoma duodenale (common hookworm), Necator americanus (American hookworm) in single or mixed infections.
Efficacy varies as a function of such factors as preexisting diarrhea and gastrointestinal transit time, degree of infection, and helminth strains. Efficacy rates derived from various studies are shown in the table below:
| Pinworm (enterobiasis) | Whipworm (trichuriasis) | Common Roundworm (ascariasis) | Hookworm | |
| Cure rates mean | 95% | 68% | 98% | 96% |
| Egg reduction mean | — | 93% | 99% | 99% |
History
There is currently no drug history available for this drug.
Other Information
Mebendazole is a (synthetic) broad-spectrum anthelmintic available as chewable tablets, each containing 100 mg of mebendazole. Inactive ingredients are: anhydrous lactose NF, corn starch, magnesium stearate, microcrystalline cellulose, sodium lauryl sulfate, sodium saccharin, sodium starch glycolate, stearic acid, and FD&C Yellow #6.
Mebendazole is methyl 5-benzoylbenzimidazole-2-carbamate and has the following structural formula:
Molecular Formula: C16H13N3O3
Mebendazole is a white to slightly yellow powder with a molecular weight of 295.29. It is less than 0.05% soluble in water, dilute mineral acid solutions, alcohol, ether and chloroform, but is soluble in formic acid.
Sources
Mebendazole Manufacturers
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Physicians Total Care, Inc.
![Mebendazole Tablet, Chewable [Physicians Total Care, Inc.]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Mebendazole | Physicians Total Care, Inc.
The same dosage schedule applies to children and adults. The tablet may be chewed, swallowed, or crushed and mixed with food.
Pinworm (enterobiasis) Whipworm (trichuriasis) Common Roundworm (ascariasis) Hookworm Dose 1 tablet, once 1 tablet morning and evening for 3 consecutive days 1 tablet morning and evening for 3 consecutive days 1 tablet morning and evening for 3 consecutive daysIf the patient is not cured three weeks after treatment, a second course of treatment is advised. No special procedures, such as fasting or purging, are required.
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Bryant Ranch Prepack
Mebendazole | Bryant Ranch Prepack
The same dosage schedule applies to children and adults. The tablet may be chewed, swallowed, or crushed and mixed with food.
Pinworm (enterobiasis) Whipworm (trichuriasis) Common Roundworm (ascariasis) Hookworm Dose 1 tablet, once 1 tablet morning and evening for 3 consecutive days 1 tablet morning and evening for 3 consecutive days 1 tablet morning and evening for 3 consecutive daysIf the patient is not cured three weeks after treatment, a second course of treatment is advised. No special procedures, such as fasting or purging, are required.
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American Pharmaceutical Ingredients Llc
Mebendazole | American Pharmaceutical Ingredients Llc
There is currently no dosage information available for this product. We apologize for any inconvenience.
![Mebendazole Tablet, Chewable [Bryant Ranch Prepack]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=c338415f-41e0-071d-8c51-a80a02ebf2cd&name=label1datamaxfda708.jpg)
![Mebendazole Powder [American Pharmaceutical Ingredients Llc]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=1bff67aa-be77-4c7d-9a54-ee486a3d1567&name=328.jpg)
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