Methenamine Mandelate
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Questions & Answers
Side Effects & Adverse Reactions
Methenamine mandelate should be avoided in patients with gout because it may precipitate urate crystals in their urine. A similar situation may arise in patients with a predisposition to the formation of uric acid stones.
Methenamine preparations should not be given to patients taking sulfonamides because some sulfonamides may form an insoluble precipitate with formaldehyde in the urine.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
Methenamine mandelate is indicated for the suppression or elimination of bacteriuria associated with pyelonephritis, cystitis, and other chronic urinary tract infections; also those neurologic diseases leading to an infected residual urine. When used as recommended, methenamine mandelate is particularly suitable for long-term therapy because of its safety and because resistance to the nonspecific bactericidal action of formaldehyde does not develop. Pathogens resistant to other antibacterial agents may respond to methenamine mandelate because of the nonspecific effect of formaldehyde formed in an acid urine.
Prophylactic Use Rationale: Urine is a good culture medium for many urinary pathogens. Inoculation by a few organisms (relapse or reinfection) may lead to bacteriuria in susceptible individuals. Thus, the rationale of management in recurring urinary tract infection (bacteriuria) is to change the urine from a growth-supporting to a growth-inhibiting medium. There is a growing body of evidence that long-term administration of methenamine mandelate can prevent the recurrence of bacteriuria in patients with chronic pyelonephritis.
Therapeutic Use Rationale: Methenamine mandelate helps to sterilize the urine, and in some situations in which underlying pathologic conditions prevent sterilization by any means, it can help to suppress the bacteriuria. Methenamine mandelate should not be used alone for acute infections with parenchymal involvement causing systemic symptoms such as chills and fever. A thorough diagnostic investigation as a part of the overall management of the urinary tract infection should accompany the use of methenamine mandelate.
History
There is currently no drug history available for this drug.
Other Information
Methenamine mandelate, a urinary antibacterial agent, is the chemical combination of mandelic acid with methenamine. Methenamine mandelate is available for oral use as film-coated tablets.
Methenamine mandelate tablets contain 1000 mg (1 g) methenamine mandelate and the following inactive ingredients: croscarmellose sodium, FD&C blue #2 aluminum lake, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polyvinyl alcohol, silicon dioxide, talc and tItanium dioxide.
Sources
Methenamine Mandelate Manufacturers
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Seton Pharmaceuticals
![Methenamine Mandelate Tablet, Film Coated [Seton Pharmaceuticals]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Methenamine Mandelate | Seton Pharmaceuticals
The average adult dose is 4 g a day given as 1 g tablet after each meal and at bedtime. Children 6 to 12 years of age should receive half the adult dose; one-half tablet 4 times a day.
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Edenbridge Pharmaceuticals, Llc
Methenamine Mandelate | Edenbridge Pharmaceuticals, Llc
The average adult dose is 4 grams daily given as 1 gram after each meal and at bedtime. Children 6 to 12 should receive half the adult dose, and children under 6 years of age should receive 250 mg per 30 lb body weight, four times daily. (See chart) Since an acid urine is essential for antibacterial activity, with maximum efficacy occurring at pH 5.5 or below, restriction of alkalinizing foods and medication is thus desirable. If testing of urine pH reveals the need, supplemental acidification should be given.
Dosages Dosage Adults
Pediatric
Patients
Tablets
Tablets
1000mg
1 tablet qid
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500mg
2 tablets qid
(Ages 6-12)
1 tablet qid
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Bryant Ranch Prepack
Methenamine Mandelate | Bryant Ranch Prepack
The average adult dose is 4 g a day given as 1 g tablet after each meal and at bedtime. Children 6 to 12 years of age should receive half the adult dose; one-half tablet 4 times a day.
![Methenamine Mandelate Tablet [Edenbridge Pharmaceuticals, Llc]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=cc299e8a-cf9a-4dc6-b6e6-972141e59296&name=methenamine2.jpg)
![Methenamine Mandelate Tablet, Film Coated [Bryant Ranch Prepack]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=9dfb9936-1136-4c2f-a98f-1fae3fcf70d2&name=49371.jpg)
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