Milk Of Magnesia Original

Milk Of Magnesia Original

Milk Of Magnesia Original Recall

Get an alert when a recall is issued.

Questions & Answers

Side Effects & Adverse Reactions

Embryofetal Toxicity

Some epidemiologic studies suggest that exposure to sulfamethoxazole and trimethoprim during pregnancy may be associated with an increased risk of congenital malformations, particularly neural tube defects, cardiovascular malformations, urinary tract defects, oral clefts, and club foot. If sulfamethoxazole and trimethoprim is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be advised of the potential hazards to the fetus.

Hypersensitivity and Other Fatal Reactions

Fatalities associated with the administration of sulfonamides, although rare, have occurred due to severe reactions, including Stevens-Johnson syndrome, toxic epidermal necrolysis, fulminant hepatic necrosis, agranulocytosis, aplastic anemia and other blood dyscrasias.

Sulfonamides, including sulfonamide-containing products such as sulfamethoxazole and trimethoprim, should be discontinued at the first appearance of skin rash or any sign of adverse reaction. In rare instances, a skin rash may be followed by a more severe reaction, such as Stevens-Johnson syndrome, toxic epidermal necrolysis, hepatic necrosis, and serious blood disorders (see PRECAUTIONS). Clinical signs, such as rash, sore throat, fever, arthralgia, pallor, purpura or jaundice may be early indications of serious reactions.

Cough, shortness of breath, and pulmonary infiltrates are hypersensitivity reactions of the respiratory tract that have been reported in association with sulfonamide treatment.

Thrombocytopenia

Sulfamethoxazole and trimethoprim-induced thrombocytopenia may be an immune-mediated disorder. Severe cases of thrombocytopenia that are fatal or life threatening have been reported. Thrombocytopenia usually resolves within a week upon discontinuation of sulfamethoxazole and trimethoprim.

Streptococcal Infections and Rheumatic Fever

The sulfonamides should not be used for treatment of group A β-hemolytic streptococcal infections. In an established infection, they will not eradicate the streptococcus and, therefore, will not prevent sequelae such as rheumatic fever.

Clostridium Difficile
Associated Diarrhea

Clostridium difficile
associated diarrhea (CDAD) has been reported with use of nearly all antibacterial agents, including sulfamethoxazole and trimethoprim, and may range in severity from mild diarrhea to fatal colitis. Treatment with antibacterial agents alters the normal flora of the colon leading to overgrowth of C. difficile.

C. difficile
produces toxins A and B which contribute to the development of CDAD. Hypertoxin producing strains of C. difficile cause increased morbidity and mortality, as these infections can be refractory to antimicrobial therapy and may require colectomy. CDAD must be considered in all patients who present with diarrhea following antibiotic use. Careful medical history is necessary since CDAD has been reported to occur over two months after the administration of antibacterial agents.

If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C. difficile may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. difficile, and surgical evaluation should be instituted as clinically indicated.

Adjunctive Treatment with Leucovorin for Pneumocystis jiroveci Pneumonia

Treatment failure and excess mortality were observed when trimethoprim-sulfamethoxazole was used concomitantly with leucovorin for the treatment of HIV positive patients with Pneumocystis jiroveci pneumonia in a randomized placebo controlled trial.6 Co-administration of trimethoprim-sulfamethoxazole and leucovorin during treatment of Pneumocystis jiroveci pneumonia should be avoided.


Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses


To reduce the development of drug-resistant bacteria and maintain the effectiveness of sulfamethoxazole and trimethoprim tablets, USP and other antibacterial drugs, sulfamethoxazole and trimethoprim tablets, USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to empiric selection of therapy.

Urinary Tract Infections

For the treatment of urinary tract infections due to susceptible strains of the following organisms: Escherichia coli, Klebsiella species, Enterobacter species, Morganella morganii, Proteus mirabilis and Proteus vulgaris. It is recommended that initial episodes of uncomplicated urinary tract infections be treated with a single effective antibacterial agent rather than the combination.

Acute Otitis Media

For the treatment of acute otitis media in pediatric patients due to susceptible strains of Streptococcus pneumoniae or Haemophilus influenzae when in the judgment of the physician sulfamethoxazole and trimethoprim tablets offer some advantage over the use of other antimicrobial agents. To date, there are limited data on the safety of repeated use of sulfamethoxazole and trimethoprim tablets, USP in pediatric patients under two years of age. Sulfamethoxazole and trimethoprim tablets, USP are not indicated for prophylactic or prolonged administration in otitis media at any age.

Acute Exacerbations of Chronic Bronchitis in Adults

For the treatment of acute exacerbations of chronic bronchitis due to susceptible strains of Streptococcus pneumoniae or Haemophilus influenzae when a physician deems that  sulfamethoxazole and trimethoprim tablets, USP could offer some advantage over the use of a single antimicrobial agent.

Shigellosis

For the treatment of enteritis caused by susceptible strains of Shigella flexneri and Shigella sonnei when antibacterial therapy is indicated.



Pneumocystis jiroveci Pneumonia

For the treatment of documented Pneumocystis jiroveci pneumonia and for prophylaxis against P.jiroveci pneumonia in individuals who are immunosuppressed and considered to be at an increased risk of developing P. jiroveci pneumonia.

Traveler's Diarrhea in Adults

For the treatment of traveler's diarrhea due to susceptible strains of enterotoxigenic E. coli.

History

There is currently no drug history available for this drug.

Other Information


Sulfamethoxazole and trimethoprim is a synthetic antibacterial combination product available in DS (double strength) tablets, each containing 800 mg sulfamethoxazole and 160 mg trimethoprim; in tablets, each containing 400 mg sulfamethoxazole and 80 mg trimethoprim for oral administration.

Sulfamethoxazole is N1-(5-methyl-3-isoxazolyl)sulfanilamide; the molecular formula is C10H11N3O3S. It is a white to off-white, practically odorless, crystalline powder, tasteless compound with a molecular weight of 253.28 and the following structural formula:


Sulfamethoxazole Chemical Structure

Trimethoprim is 2,4-diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine; the molecular formula is C14H18N4O3. It is a white or cream-colored crystals or crystalline powder with a molecular weight of 290.3 and the following structural formula:


Trimethoprim Chemical Structure

Inactive Ingredients: Docusate sodium, magnesium stearate, pregelatinized starch (maize), sodium benzoate, and sodium starch glycolate.

Milk Of Magnesia Original Manufacturers


  • Tya Pharmaceuticals
    Milk Of Magnesia Original (Magnesium Hydroxide) Liquid [Tya Pharmaceuticals]
  • Best Choice
    Milk Of Magnesia Original (Magnesium Hydroxide) Suspension [Best Choice]
  • Nash-finch Company
    Milk Of Magnesia Original (Magnesium Hydroxide) Suspension [Nash-finch Company]
  • Premier Value
    Milk Of Magnesia Original (Magnesium Hydroxide) Suspension [Premier Value]
  • Walgreens
    Milk Of Magnesia Original (Magnesium Hydroxide) Suspension [Walgreens]
  • Select Brand
    Milk Of Magnesia Original (Magnesium Hydroxide) Suspension [Select Brand]
  • Cvs
    Milk Of Magnesia Original (Magnesium Hydroxide) Suspension [Cvs]
  • Dollar General
    Milk Of Magnesia Original (Magnesium Hydroxide) Suspension [Dollar General]
  • Premier Value
    Milk Of Magnesia Original (Magnesium Hydroxide) Suspension [Premier Value]
  • Select Brand
    Milk Of Magnesia Original (Magnesium Hydroxide) Suspension [Select Brand]
  • Aaron Industries Inc.
    Milk Of Magnesia Original (Phillips Milk Of Magnesia Original) Suspension [Aaron Industries Inc.]
  • Geri-care Pharmaceuticals, Corp
    Milk Of Magnesia Original (Magnesium Hydroxide) Liquid [Geri-care Pharmaceuticals, Corp]
  • Major Pharmaceuticals Inc.
    Milk Of Magnesia Original (Magnesium Hydroxide) Liquid [Major Pharmaceuticals Inc.]
  • Preferred Pharmaceuticals, Inc.
    Milk Of Magnesia Original (Magnesium Hydroxide) Liquid [Preferred Pharmaceuticals, Inc.]
  • Atlantic Biologicals Corps
    Milk Of Magnesia Original (Magnesium Hydroxide) Liquid [Atlantic Biologicals Corps]
  • Chain Drug Marketing Association
    Milk Of Magnesia Original (Magnesium Hydroxide) Liquid [Chain Drug Marketing Association]
  • Mckesson
    Milk Of Magnesia Original (Magnesium Hydroxide) Liquid [Mckesson]

Login To Your Free Account