Neut Sodium Bicarbonate

Neut Sodium Bicarbonate Manufacturers

• Hospira, Inc.
  

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  Neut Sodium Bicarbonate | Hospira, Inc.

  

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  One vial (5 mL) of Neut added to a liter (1000 mL) of any of the following Hospira parenteral solutions will increase the pH to a more physiologic range. Specific pH may vary slightly from lot to lot.

  Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS.

  Product

  List

  5% Alcohol in 5% Dextrose Injection, USP

  1500

  2.5% Dextrose Inj., USP

  1508

  5% Dextrose Inj., USP

  1522

  10% Dextrose Inj., USP

  1530

  20% Dextrose Inj., USP

  1535

  Ringer’s Injection, USP

  1582

  0.9% Sodium Chloride Inj., USP

  1583

  Sodium Lactate Inj., USP (1/6 Molar)

  1587

  Addition of one vial of Neut to one-half liter (500 mL) is recommended to achieve a more physiologic pH of the following Hospira parenteral solutions:

  Product

  List

  6% Dextran 70 and 0.9% Sodium Chloride Injection

  1505

  6% Dextran 70 and 5% Dextrose Injection

  1507

  Note: Some products, e.g., Aminosyn® solutions and those Ionosol® and Normosol® formulas containing dextrose will NOT be brought to near physiologic pH by the addition of Neut. This is due to the relatively high buffer capacity of these fluids.

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• Hospira, Inc.
  

  ×

  Neut Sodium Bicarbonate | Hospira, Inc.

  

  ---

  One vial (5 mL) of Neut added to a liter (1000 mL) of any of the following Hospira parenteral solutions will increase the pH to a more physiologic range. Specific pH may vary slightly from lot to lot.

  Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. See PRECAUTIONS.

  Product

  List

  5% Alcohol in 5% Dextrose Injection, USP

  1500

  2.5% Dextrose Inj., USP

  1508

  5% Dextrose Inj., USP

  1522

  10% Dextrose Inj., USP

  1530

  20% Dextrose Inj., USP

  1535

  Ringer’s Injection, USP

  1582

  0.9% Sodium Chloride Inj., USP

  1583

  Sodium Lactate Inj., USP (1/6 Molar)

  1587

  Addition of one vial of Neut to one-half liter (500 mL) is recommended to achieve a more physiologic pH of the following Hospira parenteral solutions:

  Product

  List

  6% Dextran 70 and 0.9% Sodium Chloride Injection

  1505

  6% Dextran 70 and 5% Dextrose Injection

  1507

  Note: Some products, e.g., AminosynTM solutions and those IonosolTM and NormosolTM formulas containing dextrose will NOT be brought to near physiologic pH by the addition of Neut. This is due to the relatively high buffer capacity of these fluids.

  COMPATIBILITY & EFFECTIVENESS OF NEUT WITH ADDITIVES TO 5% DEXTROSE INJECTION (D5-W)
  When medications are added to intravenous solutions, the resultant admixtures may or may not be compatible in solutions containing Neut (4% sodium bicarbonate additive solution).

  Following is a list of medications each added to one liter of 5% Dextrose Injection, USP (D5‑W) classified according to their effect with Neut (4% sodium bicarbonate additive solution).

  1. Neut Compatible with Admixtures for 24 Hours

  Conc./liter

      ACTHAR® (ACTH)

  40 units

      Aqua-Mephyton® (Vitamin K1)

  10 mg

      Aramine® (metaraminol) Bitartrate

  100 mg†

      Atropine Sulfate

  0.4 mg

      Calcium Chloride

  1 g

      Calcium Gluceptate

  1.1 g

      Compazine® (prochlorperazine) Edisylate

  10 mg

      Crystodigin® (digitoxin)

  0.2 mg

      Demerol® (meperidine) HCl

  100 mg

      Ergonovine Maleate

  0.2 mg

      Erythrocin® (erythromycin) Lactobionate

  1 g

      Fungizone® (amphotericin B)

  50 mg

      Ilotycin® (erythromycin) Gluceptate

  1 g

      Innovar® (droperidol and fentanyl)

  1.0 mL

      Keflin® (cephalothin) Sodium

  4 g

      Lidocaine HCl

  1 g

      M.V.I.TM (multivitamin infusion)

  10 mL†

      Neosynephrine® (phenylephrine) HCl

  10 mg

      Panheparin® (heparin sodium)

  20,000 units

      Penicillin G Potassium

  100,000,000 units

      Pitocin® (oxytocin)

  5 units

      Potassium Chloride

  120 mEq

      Sodium Iodide

  1 g

      (promazine) HCl

  100 mg

      Vancocin® (vancomycin) HCl

  500 mg

      Wydase® (hyaluronidase)

  150 units

  †Requires 2 vials of Neut to bring admixture to approximate neutrality.

  2. Neut Incompatible –Additive Inactivated at Neutral pH

  Conc./liter

      Epinephrine

  4 mg

      IsuprelTM (isoproterenol) HCl

  1 mg

      LevophedTM (levarterenol) Bitartrate

  8 mg

      QuelicinTM (succinylcholine chloride)

  1 g

  3. Neut Ineffective -Additive High in Titratable Acidity

  Conc./liter

      Achromycin® (tetracycline) HCl

  500 mg

      Aureomycin® (chlortetracycline) HCl

  500 mg

      Bejectal w/C (B complex and C)

  10 mL

      Kantrex® (kanamycin) Sulfate

  1 g

  4. Neut Not Indicated –Admixture Already At or Near Neutrality

  Conc./liter

      Gantrisin® (sulfisoxazole) Diethanolamine

  4 g

      Hydrocortone® (hydrocortisone) Phosphate

  100 mg

      Prostaphlin® (oxacillin) Sodium

  500 mg

      Sodium Bicarbonate

  3.75 g

      Solu-Cortef ® (hydrocortisone sodium succinate)

  250 mg

  It should be noted that the admixtures were evaluated for physical compatibility, not for pharmacological compatibility. It, therefore, would be erroneous to circumvent medical judgment which must be involved in administering any solution that appears to be compatible on the basis of having no visible haze or precipitate. The inclusion of drugs in this study of their compatibility in solution does not imply their therapeutic usefulness or safety. This matter remains the judgment of the prescribing physician.

  NOTE: The compatibility information contained herein is based on the studies involving Hospira dextrose only. Variations in compatibility could occur due to lot-to-lot variations or formula changes in the additives or dextrose solutions of other manufacturers.

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