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Uses
Donepezil hydrochloride USP is indicated for the treatment of dementia of the Alzheimer's type. Efficacy has been demonstrated in patients with mild, moderate, and severe Alzheimer’s disease.
History
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Other Information
Donepezil hydrochloride USP is a reversible inhibitor of the enzyme acetylcholinesterase, known chemically as (±)-2, 3-dihydro-5, 6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-1H-inden-1-one hydrochloride.
Donepezil hydrochloride USP is commonly referred to in the pharmacological literature as E2020. It has an empirical formula of C24H29NO3HCl and a molecular weight of 415.96. Donepezil hydrochloride USP is a white crystalline powder and is freely soluble in chloroform, soluble in water and in glacial acetic acid, slightly soluble in ethanol and in acetonitrile and practically insoluble in ethyl acetate and in n-hexane.
Donepezil hydrochloride ODT USP is available for oral administration. Each donepezil hydrochloride ODT USP contains 5 or 10 mg of donepezil hydrochloride USP. Inactive ingredients are mannitol, crospovidone, sucralose, sodium chloride, ferric oxide yellow and magnesium stearate.
Sources
Old Spice Wild Collection Foxcrest Invisible Manufacturers
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Procter & Gamble Manufacturing Company
Old Spice Wild Collection Foxcrest Invisible | Macleods Pharmaceuticals Limited
2.1 Dosing in Mild to Moderate Alzheimer's DiseaseThe recommended starting dosage of orally disintegrating tablets, USP are 5 mg administered once per day in the evening, just prior to retiring. The maximum recommended dosage of donepezil hydrochloride orally disintegrating tablets in patients with mild to moderate Alzheimer’s disease is 10 mg per day. A dose of 10 mg should not be administered until patients have been on a daily dose of 5 mg for 4 to 6 weeks.
2.2 Dosing in Moderate to Severe Alzheimer's DiseaseThe recommended starting dosage of donepezil hydrochloride orally disintegrating tablets are 5 mg administered once per day in the evening, just prior to retiring.
A dose of 10 mg should not be administered until patients have been on a daily dose of 5 mg for 4 to 6 weeks.
2.3 Administration InformationDonepezil hydrochloride orally disintegrating tablets should be taken in the evening, just prior to retiring. Donepezil hydrochloride orally disintegrating tablets can be taken with or without food.
Allow donepezil hydrochloride orally disintegrating tablets to dissolve on the tongue and follow with water.
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