Pilocarpine Hydrochloride Solution
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Questions & Answers
Side Effects & Adverse Reactions
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Legal Issues
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FDA Safety Alerts
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Manufacturer Warnings
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FDA Labeling Changes
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Uses
Pilocarpine Hydrochloride Ophthalmic Solution is indicated for the:
History
There is currently no drug history available for this drug.
Other Information
Pilocarpine Hydrochloride Ophthalmic Solution is a cholinergic agonist prepared as a sterile topical ophthalmic solution. The active ingredient is represented by the chemical structure:
Established name: pilocarpine hydrochloride Chemical name: 2(3H)-furanone, 3-ethyldihydro-4-[(1-methyl-1H-imidazol-5-yl)-methyl]- monohydrochloride, (3S-cis)-. Molecular Formula: C11H16N2O2 • HCl. Molecular Weight: 244.72.
Each mL of Pilocarpine Hydrochloride Ophthalmic Solution contains: Active: pilocarpine hydrochloride 1% (10 mg/mL), 2% (20 mg/mL), or 4% (40 mg/mL). Preservative: benzalkonium chloride 0.01%. Inactives: hypromellose 2910, boric acid, sodium citrate, sodium chloride (present in 1% only); hydrochloric acid and/or sodium hydroxide (to adjust pH); purified water. Pilocarpine Hydrochloride Ophthalmic Solution has a pH of 3.5 to 5.5 and an osmolality of 290 to 350 mOsm/kg (1% and 2% products) and 550 to 600 mOsm/kg (4% product).
Sources
Pilocarpine Hydrochloride Solution Manufacturers
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Falcon Pharmaceuticals, Ltd.
![Pilocarpine Hydrochloride Solution [Falcon Pharmaceuticals, Ltd.]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Pilocarpine Hydrochloride Solution | Falcon Pharmaceuticals, Ltd.
2.1 Reduction of Elevated Intraocular Pressure (IOP) in Patients with Open-Angle Glaucoma or Ocular HypertensionOne drop of Pilocarpine Hydrochloride Ophthalmic Solution 1%, 2% or 4% should be applied topically in the eye(s) up to four times daily.
Pilocarpine-naïve patients should be started on the 1% concentration as higher concentrations are often not tolerated initially. The frequency of instillation and concentration of Pilocarpine Hydrochloride Ophthalmic Solution are determined by the severity of the elevated intraocular pressure and miotic response of the patient. To limit systemic exposure to pilocarpine, patients may be instructed to perform punctal occlusion for 2 minutes after instillation of Pilocarpine Hydrochloride Ophthalmic Solution.
2.2 Management of Acute Angle-Closure GlaucomaPrior to Pilocarpine Hydrochloride Ophthalmic Solution use, treatment with secretory suppressants and hyperosmotic agents may be needed to lower IOP below 50 mmHg and relieve iris ischemia.
For initial management of acute angle-closure glaucoma, one drop of Pilocarpine Hydrochloride Ophthalmic Solution 1% or 2% may be applied topically in the eye(s) up to three times over a 30-minute period.
If laser iridoplasty or iridomy is used to break the attack, one drop of Pilocarpine Hydrochloride Ophthalmic Solution 4% should be administered prior to the procedure. Following laser iridoplasty, one drop of Pilocarpine Hydrochloride Ophthalmic Solution 1% should be administered four times daily until an iridotomy can be performed.
2.3 Prevention of Postoperative Elevated IOP Associated with Laser SurgeryOne drop of Pilocarpine Hydrochloride Ophthalmic Solution 1%, 2% or 4% (or two drops administered five minutes apart) should be applied topically in the eye(s) 15 to 60 minutes prior to surgery.
2.4 Induction of MiosisOne drop of Pilocarpine Hydrochloride Ophthalmic Solution 1%, 2% or 4% (or two drops administered five minutes apart) should be applied topically in the eye(s).
2.5 Use with Other Topical Ophthalmic MedicationsPilocarpine may be used in combination with beta-blockers, carbonic anhydrase inhibitors, sympathomimetics or hyperosmotic agents. If more than one topical ophthalmic drug is being used, the drugs should be administered at least five (5) minutes apart.
2.6 Use in Pediatric PatientsIn children under 2 years of age, one drop of Pilocarpine Hydrochloride Ophthalmic Solution 1% should be applied topically in the eye(s) three times daily. Children 2 years of age and over should be dosed as for adults. For the induction of miosis prior to goniotomy or trabeculotomy in children, one drop of Pilocarpine Hydrochloride Ophthalmic Solution 1% or 2% should be applied topically in the eye 15 to 60 minutes prior to surgery.
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Remedyrepack Inc.
Pilocarpine Hydrochloride Solution | Remedyrepack Inc.
• Instill one drop in the eye(s) up to four times daily (2).
One drop of Pilocarpine Hydrochloride Ophthalmic Solution 1%, 2% or 4% should be applied topically in the eye(s) up to four times daily.
Pilocarpine-naïve patients should be started on the 1% concentration as higher concentrations are often not tolerated initially. The frequency of instillation and concentration of Pilocarpine Hydrochloride Ophthalmic Solution are determined by the severity of the elevated intraocular pressure and miotic response of the patient. To limit systemic exposure to pilocarpine, patients may be instructed to perform punctal occlusion for 2 minutes after instillation of Pilocarpine Hydrochloride Ophthalmic Solution.
Prior to Pilocarpine Hydrochloride Ophthalmic Solution use, treatment with secretory suppressants and hyperosmotic agents may be needed to lower IOP below 50 mmHg and relieve iris ischemia.
For initial management of acute angle-closure glaucoma, one drop of Pilocarpine Hydrochloride Ophthalmic Solution 1% or 2% may be applied topically in the eye(s) up to three times over a 30-minute period.
If laser iridoplasty or iridomy is used to break the attack, one drop of Pilocarpine Hydrochloride Ophthalmic Solution 4% should be administered prior to the procedure. Following laser iridoplasty, one drop of Pilocarpine Hydrochloride Ophthalmic Solution 1% should be administered four times daily until an iridotomy can be performed.
One drop of Pilocarpine Hydrochloride Ophthalmic Solution 1%, 2% or 4% (or two drops administered five minutes apart) should be applied topically in the eye(s) 15 to 60 minutes prior to surgery.
One drop of Pilocarpine Hydrochloride Ophthalmic Solution 1%, 2% or 4% (or two drops administered five minutes apart) should be applied topically in the eye(s).
Pilocarpine may be used in combination with beta-blockers, carbonic anhydrase inhibitors, sympathomimetics or hyperosmotic agents. If more than one topical ophthalmic drug is being used, the drugs should be administered at least five (5) minutes apart.
In children under 2 years of age, one drop of Pilocarpine Hydrochloride Ophthalmic Solution 1% should be applied topically in the eye(s) three times daily. Children 2 years of age and over should be dosed as for adults. For the induction of miosis prior to goniotomy or trabeculotomy in children, one drop of Pilocarpine Hydrochloride Ophthalmic Solution 1% or 2% should be applied topically in the eye 15 to 60 minutes prior to surgery.
![Pilocarpine Hydrochloride Solution [Remedyrepack Inc. ]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=d87192c5-c6b4-4d56-95b1-bb242afed3c1&name=MM2.jpg)
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