Polymyxin B Sulfate And Trimethoprim
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Questions & Answers
Side Effects & Adverse Reactions
NOT FOR INJECTION INTO THE EYE.
If a sensitivity reaction to polymyxin B sulfate and trimethoprim ophthalmic solution occurs, discontinue use.
Polymyxin B sulfate and trimethoprim ophthalmic solution is not indicated for the prophylaxis or treatment of ophthalmia neonatorum.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
Polymyxin B sulfate and trimethoprim ophthalmic solution is indicated in the treatment of surface ocular bacterial infections, including acute bacterial conjunctivitis, and blepharoconjunctivitis, caused by susceptible strains of the following microorganisms: Staphylococcus aureus, Staphylococcus epidermidis,Streptococcus pneumoniae, Streptococcus viridans, Haemophilus influenzae and Pseudomonasaeruginosa.**
**Efficacy for this organism in this organ system was studied in fewer than 10 infections.
History
There is currently no drug history available for this drug.
Other Information
Polymyxin B Sulfate and Trimethoprim Ophthalmic Solution USP* is a sterile antimicrobial solution for topical ophthalmic use. It has a pH of 4.0 to 6.2 and osmolality of 270 to 310 mOsm/kg. Trimethoprim sulfate, a white, odorless, crystalline powder, is represented by the following structural formula:
C28H38N8O10S
Mol. Wt. 678.72
Chemical Name: Trimethoprim sulfate, 2,4-diamino-5-(3,4 5-trimethoxybenzyl)pyrimidine sulfate (2:1)
Polymyxin B sulfate is the sulfate salt of polymyxin B1 and B2 which are produced by the growth of Bacilluspolymyxa (Prazmowski) Migula (Fam. Bacillaceae) . It has a potency of not less than 6,000 polymyxin B units per mg, calculated on an anhydrous basis. The structural formula is:
Each mL Contains: ACTIVES: Polymyxin B Sulfate equal to 10,000 polymyxin B units, Trimethoprim Sulfate (equivalent to trimethoprim 1 mg); INACTIVES: Sodium Chloride, Purified Water. Sulfuric acid and, if necessary, sodium hydroxide may be added to adjust pH (4.0 – 6.2). PRESERVATIVE ADDED: Benzalkonium Chloride 0.004%.
Sources
Polymyxin B Sulfate And Trimethoprim Manufacturers
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Lake Erie Medical & Surgical Supply Dba Quality Care Products Llc
![Polymyxin B Sulfate And Trimethoprim (Polymyxin B Sulfate And Trimethoprim Sulfate) Solution/ Drops [Lake Erie Medical & Surgical Supply Dba Quality Care Products Llc]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Polymyxin B Sulfate And Trimethoprim | Lake Erie Medical & Surgical Supply Dba Quality Care Products Llc
In mild to moderate infections, instill one drop in the affected eye(s) every three hours (maximum of 6 doses per day) for a period of 7 to 10 days.
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Bausch & Lomb Incorporated
Polymyxin B Sulfate And Trimethoprim | Cantrell Drug Company
FOR SLOW INTRAVENOUS USE. PRESERVATIVE FREE INJECTION SOLUTION.
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Physicians Total Care, Inc.
Polymyxin B Sulfate And Trimethoprim | Physicians Total Care, Inc.
In mild to moderate infections, instill one drop in the affected eye(s) every three hours (maximum of 6 doses per day) for a period of 7 to 10 days.
![Polymyxin B Sulfate And Trimethoprim (Polymyxin B Sulfate And Trimethoprim Sulfate) Solution/ Drops [Bausch & Lomb Incorporated]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=d3f37738-336f-40e1-a7ee-81cb924b8cd7&name=52533-160-43(2).jpg)
![Polymyxin B Sulfate And Trimethoprim (Polymyxin B Sulfate And Trimethoprim Sulfate) Solution/ Drops [Physicians Total Care, Inc.]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=7e5bbaef-78a3-4364-ad27-6a8536942ac4&name=4335.jpg)
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