Propranolol Hydrochloride

Propranolol Hydrochloride

Propranolol Hydrochloride Recall

Get an alert when a recall is issued.

Questions & Answers

Side Effects & Adverse Reactions

Angina Pectoris

There have been reports of exacerbation of angina and, in some cases, myocardial infarction, following abrupt discontinuance of propranolol therapy. Therefore, when discontinuance of propranolol is planned, the dosage should be gradually reduced over at least a few weeks and the patient should be cautioned against interruption or cessation of therapy without the physician’s advice. If propranolol therapy is interrupted and exacerbation of angina occurs, it usually is advisable to reinstitute propranolol therapy and take other measures appropriate for the management of angina pectoris. Since coronary artery disease may be unrecognized, it may be prudent to follow the above advice in patients considered at risk of having occult atherosclerotic heart disease who are given propranolol for other indications.

Hypersensitivity and Skin Reactions

Hypersensitivity reactions, including anaphylactic/anaphylactoid reactions, have been associated with the administration of propranolol (see ADVERSE REACTIONS).

Cutaneous reactions, including Stevens-Johnson Syndrome, toxic epidermal necrolysis, exfoliative dermatitis, erythema multiforme, and urticaria, have been reported with use of propranolol (see ADVERSE REACTIONS).

Cardiac Failure

Sympathetic stimulation may be a vital component supporting circulatory function in patients with congestive heart failure, and its inhibition by beta blockade may precipitate more severe failure. Although beta blockers should be avoided in overt congestive heart failure, some have been shown to be highly beneficial when used with close follow-up in patients with a history of failure who are well compensated and are receiving additional therapies, including diuretics as needed. Beta-adrenergic blocking agents do not abolish the inotropic action of digitalis on heart muscle.

In Patients without a History of Heart Failure, continued use of beta blockers can, in some cases, lead to cardiac failure.

Nonallergic Bronchospasm (e.g., Chronic Bronchitis, Emphysema)

In general, patients with bronchospastic lung disease should not receive beta blockers. Propranolol should be administered with caution in this setting since it may provoke a bronchial asthmatic attack by blocking bronchodilation produced by endogenous and exogenous catecholamine stimulation of beta-receptors.

Major Surgery

Chronically administered beta-blocking therapy should not be routinely withdrawn prior to major surgery, however the impaired ability of the heart to respond to reflex adrenergic stimuli may augment the risks of general anesthesia and surgical procedures.

Diabetes and Hypoglycemia

Beta-adrenergic blockade may prevent the appearance of certain premonitory signs and symptoms (pulse rate and pressure changes) of acute hypoglycemia, especially in labile insulin-dependent diabetics. In these patients, it may be more difficult to adjust the dosage of insulin.

Propranolol therapy, particularly when given to infants and children, diabetic or not, has been associated with hypoglycemia especially during fasting as in preparation for surgery. Hypoglycemia has been reported in patients taking propranolol after prolonged physical exertion and in patients with renal insufficiency.

Thyrotoxicosis

Beta-adrenergic blockade may mask certain clinical signs of hyperthyroidism. Therefore, abrupt withdrawal of propranolol may be followed by an exacerbation of symptoms of hyperthyroidism, including thyroid storm. Propranolol may change thyroid-function tests, increasing T4 and reverse T3 and decreasing T3.

Wolff-Parkinson-White Syndrome

Beta-adrenergic blockade in patients with Wolf-Parkinson-White Syndrome and tachycardia has been associated with severe bradycardia requiring treatment with a pacemaker. In one case, this result was reported after an initial dose of 5 mg propranolol.

Pheochromocytoma

Blocking only the peripheral dilator (beta) action of epinephrine with propranolol leaves its constrictor (alpha) action unopposed. In the event of hemorrhage or shock, there is a disadvantage in having both beta and alpha blockade since the combination prevents the increase in heart rate and peripheral vasoconstriction needed to maintain blood pressure.

 

Legal Issues

There is currently no legal information available for this drug.

FDA Safety Alerts

There are currently no FDA safety alerts available for this drug.

Manufacturer Warnings

There is currently no manufacturer warning information available for this drug.

FDA Labeling Changes

There are currently no FDA labeling changes available for this drug.

Uses

Hypertension

Propranolol hydrochloride tablets are indicated in the management of hypertension. It may be used alone or used in combination with other antihypertensive agents, particularly a thiazide diuretic. Propranolol hydrochloride is not indicated in the management of hypertensive emergencies.

Angina Pectoris Due to Coronary Atherosclerosis

Propranolol hydrochloride tablets are indicated to decrease angina frequency and increase exercise tolerance in patients with angina pectoris.

Atrial Fibrillation

Propranolol hydrochloride tablets are indicated to control ventricular rate in patients with atrial fibrillation and a rapid ventricular response.

Myocardial Infarction

Propranolol is indicated to reduce cardiovascular mortality in patients who have survived the acute phase of myocardial infarction and are clinically stable.

Migraine

Propranolol is indicated for the prophylaxis of common migraine headache. The efficacy of propranolol in the treatment of a migraine attack that has started has not been established, and propranolol is not indicated for such use.

Essential Tremor

Propranolol is indicated in the management of familial or hereditary essential tremor. Familial or essential tremor consists of involuntary, rhythmic, oscillatory movements, usually limited to the upper limbs. It is absent at rest, but occurs when the limb is held in a fixed posture or position against gravity and during active movement. Propranolol causes a reduction in the tremor amplitude, but not in the tremor frequency. Propranolol is not indicated for the treatment of tremor associated with Parkinsonism.

Hypertrophic Subaortic Stenosis

Propranolol improves NYHA functional class in symptomatic patients with hypertrophic subaortic stenosis.

Pheochromocytoma

Propranolol is indicated as an adjunct to alpha-adrenergic blockade to control blood pressure and reduce symptoms of catecholamine-secreting tumors.

 

History

There is currently no drug history available for this drug.

Other Information

Propranolol hydrochloride is a synthetic beta-adrenergic receptor blocking agent chemically described as 2-Propanol, 1-[(1-methylethyl)amino]-3-(1-naphthalenyloxy)-, hydrochloride,(±)-. Its molecular and structural formulae are:

MM1

C16H21NO2 • HCl                          M.W. 295.80

Propranolol hydrochloride is a stable, white crystalline solid which is readily soluble in water and ethanol.  Its molecular weight is 295.80.

Propranolol hydrochloride is available as 10 mg, 20 mg, 40 mg and 80 mg tablets for oral administration.

Propranolol Hydrochloride Tablets USP 10 mg, 20 mg, 40 mg, and 80 mg contain the following inactive ingredients: anhydrous lactose, colloidal silicon dioxide, croscarmellose sodium, D&C Yellow No. 10, magnesium stearate, microcrystalline cellulose and stearic acid.

Propranolol Hydrochloride Tablets USP 10 mg and 80 mg also contain FD&C Yellow No. 6.

Propranolol Hydrochloride Tablets USP 20 mg and 40 mg also contain FD&C Blue No. 1.

 

Propranolol Hydrochloride Manufacturers


  • Remedyrepack Inc.
    Propranolol Hydrochloride Tablet [Remedyrepack Inc. ]
  • Lake Erie Medical Dba Quality Care Products Llc
    Propranolol Hydrochloride Capsule, Extended Release [Lake Erie Medical Dba Quality Care Products Llc]
  • Blenheim Pharmacal, Inc.
    Propranolol Hydrochloride Tablet [Blenheim Pharmacal, Inc.]
  • Proficient Rx Lp
    Propranolol Hydrochloride Tablet [Proficient Rx Lp]
  • A-s Medication Solutions Llc
    Propranolol Hydrochloride Tablet [A-s Medication Solutions Llc]
  • A-s Medication Solutions Llc
    Propranolol Hydrochloride Tablet [A-s Medication Solutions Llc]
  • Direct Rx
    Propranolol Hydrochloride Tablet [Direct Rx]
  • Cardinal Health
    Propranolol Hydrochloride Tablet [Cardinal Health]
  • Tya Pharmaceuticals
    Propranolol Hydrochloride Tablet [Tya Pharmaceuticals]
  • Baxter Healthcare Corporation
    Propranolol Hydrochloride (Propranolol Hydrochloride) Injection [Baxter Healthcare Corporation]
  • Physicians Total Care, Inc.
    Propranolol Hydrochloride Tablet [Physicians Total Care, Inc.]
  • State Of Florida Doh Central Pharmacy
    Propranolol Hydrochloride (Propranolol Hydrochloride) Tablet [State Of Florida Doh Central Pharmacy]
  • State Of Florida Doh Central Pharmacy
    Propranolol Hydrochloride Tablet [State Of Florida Doh Central Pharmacy]
  • State Of Florida Doh Central Pharmacy
    Propranolol Hydrochloride (Propranolol Hydrochloride) Tablet [State Of Florida Doh Central Pharmacy]
  • General Injectables & Vaccines, Inc
    Propranolol Hydrochloride Injection [General Injectables & Vaccines, Inc]
  • Rebel Distributors Corp
    Propranolol Hydrochloride Tablet [Rebel Distributors Corp]
  • Remedyrepack Inc.
    Propranolol Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Propranolol Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Propranolol Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Propranolol Hydrochloride Capsule, Extended Release [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Propranolol Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Propranolol Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Propranolol Hydrochloride Tablet [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Propranolol Hydrochloride Capsule, Extended Release [Remedyrepack Inc. ]
  • Remedyrepack Inc.
    Propranolol Hydrochloride Tablet [Remedyrepack Inc. ]
  • Udl Laboratories, Inc.
    Propranolol Hydrochloride Tablet [Udl Laboratories, Inc.]
  • Remedyrepack Inc.
    Propranolol Hydrochloride Tablet [Remedyrepack Inc. ]
  • Qualitest Pharmaceuticals
    Propranolol Hydrochloride Tablet [Qualitest Pharmaceuticals]
  • Rebel Distributors Corp.
    Propranolol Hydrochloride Tablet [Rebel Distributors Corp.]
  • Dispensing Solutions, Inc.
    Propranolol Hydrochloride Tablet [Dispensing Solutions, Inc.]
  • Lake Erie Medical & Surgical Supply Dba Quality Care Products Llc
    Propranolol Hydrochloride Tablet [Lake Erie Medical & Surgical Supply Dba Quality Care Products Llc]
  • Physicians Total Care, Inc.
    Propranolol Hydrochloride (Propranolol) Capsule, Extended Release [Physicians Total Care, Inc.]
  • Unit Dose Services
    Propranolol Hydrochloride Tablet [Unit Dose Services]
  • Unit Dose Services
    Propranolol Hydrochloride Tablet [Unit Dose Services]
  • Sandoz Inc
    Propranolol Hydrochloride Injection, Solution [Sandoz Inc]
  • Pliva Inc.
    Propranolol Hydrochloride Tablet [Pliva Inc.]
  • Preferred Pharmaceuticals, Inc.
    Propranolol Hydrochloride Tablet [Preferred Pharmaceuticals, Inc.]
  • Watson Laboratories, Inc.
    Propranolol Hydrochloride Tablet [Watson Laboratories, Inc.]
  • Pd-rx Pharmaceuticals, Inc.
    Propranolol Hydrochloride Tablet [Pd-rx Pharmaceuticals, Inc.]
  • Upsher-smith Laboratories, Inc.
    Propranolol Hydrochloride Capsule, Extended Release [Upsher-smith Laboratories, Inc.]
  • Major Pharmaceuticals
    Propranolol Hydrochloride Tablet [Major Pharmaceuticals]
  • Remedyrepack Inc.
    Propranolol Hydrochloride (Propranolol Hydrochloride ) Tablet [Remedyrepack Inc. ]
  • Unit Dose Services
    Propranolol Hydrochloride Capsule, Extended Release [Unit Dose Services]
  • Bryant Ranch Prepack
    Propranolol Hydrochloride Capsule, Extended Release [Bryant Ranch Prepack]
  • Bryant Ranch Prepack
    Propranolol Hydrochloride Tablet [Bryant Ranch Prepack]
  • Bryant Ranch Prepack
    Propranolol Hydrochloride Tablet [Bryant Ranch Prepack]
  • Bryant Ranch Prepack
    Propranolol Hydrochloride Tablet [Bryant Ranch Prepack]
  • Bryant Ranch Prepack
    Propranolol Hydrochloride Tablet [Bryant Ranch Prepack]
  • Ncs Healthcare Of Ky, Inc Dba Vangard Labs
    Propranolol Hydrochloride Tablet [Ncs Healthcare Of Ky, Inc Dba Vangard Labs]
  • Remedyrepack Inc.
    Propranolol Hydrochloride Tablet [Remedyrepack Inc. ]
  • Ncs Healthcare Of Ky, Inc Dba Vangard Labs
    Propranolol Hydrochloride Tablet [Ncs Healthcare Of Ky, Inc Dba Vangard Labs]
  • Cardinal Health
    Propranolol Hydrochloride Injection, Solution [Cardinal Health]
  • A-s Medication Solutions Llc
    Propranolol Hydrochloride Tablet [A-s Medication Solutions Llc]
  • Remedyrepack Inc.
    Propranolol Hydrochloride Tablet [Remedyrepack Inc. ]
  • Breckenridge Pharmaceutical, Inc.
    Propranolol Hydrochloride Capsule, Extended Release [Breckenridge Pharmaceutical, Inc.]
  • Cardinal Health
    Propranolol Hydrochloride Tablet [Cardinal Health]
  • Actavis Elizabeth Llc
    Propranolol Hydrochloride Capsule, Extended Release [Actavis Elizabeth Llc]
  • Physicians Total Care, Inc.
    Propranolol Hydrochloride Capsule, Extended Release [Physicians Total Care, Inc.]
  • Heritage Pharmaceuticals Inc.
    Propranolol Hydrochloride Tablet [Heritage Pharmaceuticals Inc.]
  • Aidarex Pharmaceuticals Llc
    Propranolol Hydrochloride Tablet [Aidarex Pharmaceuticals Llc]
  • Pd-rx Pharmaceuticals, Inc.
    Propranolol Hydrochloride Tablet [Pd-rx Pharmaceuticals, Inc.]
  • State Of Florida Doh Central Pharmacy
    Propranolol Hydrochloride Tablet [State Of Florida Doh Central Pharmacy]
  • State Of Florida Doh Central Pharmacy
    Propranolol Hydrochloride Tablet [State Of Florida Doh Central Pharmacy]
  • Zydus Pharmaceuticals (Usa) Inc.
    Propranolol Hydrochloride Capsule, Extended Release [Zydus Pharmaceuticals (Usa) Inc.]
  • Cadila Healthcare Limited
    Propranolol Hydrochloride Capsule, Extended Release [Cadila Healthcare Limited]
  • Remedyrepack Inc.
    Propranolol Hydrochloride Tablet [Remedyrepack Inc. ]
  • Lake Erie Medical Dba Quality Care Products Llc
    Propranolol Hydrochloride Tablet [Lake Erie Medical Dba Quality Care Products Llc]
  • Aphena Pharma Solutions – Tennessee, Llc
    Propranolol Hydrochloride Tablet [Aphena Pharma Solutions – Tennessee, Llc]
  • Mylan Pharmaceuticals Inc.
    Propranolol Hydrochloride Capsule, Extended Release [Mylan Pharmaceuticals Inc.]
  • Carilion Materials Management
    Propranolol Hydrochloride Tablet [Carilion Materials Management]
  • Bryant Ranch Prepack
    Propranolol Hydrochloride Tablet [Bryant Ranch Prepack]
  • Mylan Pharmaceuticals Inc.
    Propranolol Hydrochloride Tablet [Mylan Pharmaceuticals Inc.]
  • Carilion Materials Management
    Propranolol Hydrochloride Capsule, Extended Release [Carilion Materials Management]
  • Remedyrepack Inc.
    Propranolol Hydrochloride Tablet [Remedyrepack Inc. ]
  • Northstar Rxllc
    Propranolol Hydrochloride Tablet [Northstar Rxllc]
  • Golden State Medical Supply, Inc.
    Propranolol Hydrochloride Capsule, Extended Release [Golden State Medical Supply, Inc.]
  • Cardinal Health
    Propranolol Hydrochloride Tablet [Cardinal Health]
  • Clinical Solutions Wholesale
    Propranolol Hydrochloride Tablet [Clinical Solutions Wholesale]

Login To Your Free Account