Tolazine
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Questions & Answers
Side Effects & Adverse Reactions
Keep out of reach of children. Not for human use.
This drug is for use in horses only and not for use in food-producing animals.
Avoid contact with eyes, skin and mucous membranes. In case of eye contact flush with plenty of water. Exposed skin should be washed with soap and water. In case of accidental oral exposure or injection, seek emergency medical attention.
Users with cardiovascular disease (for example, hypertension or ischemic heart disease) should take special precautions to avoid accidental exposure to this product.
To report adverse reactions in users or to obtain a copy of the material safety data sheet for this product, call 1-800-932-5676.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
Tolazine should be used in horses when it is desirable to reverse the effects of sedation and analgesia caused by xylazine.
History
There is currently no drug history available for this drug.
Other Information
Tolazine contains tolazoline hydrochloride with the chemical name 1H-Imidazole,4,5-dihydro-2-(phenylmethyl)-monohydrochloride. Tolazoline hydrochloride has a molecular weight of 196.68 and the molecular formula is C10H12N2•HCI. The structural formula is
Each mL contains: tolazoline hydrochloride equivalent to 100 mg base activity, chlorobutanol 5.0 mg, tartaric acid 7.8 mg, sodium citrate dihydrate 7.8 mg and water for injection. The pH is adjusted with hydrochloric acid and sodium citrate.
Sources
Tolazine Manufacturers
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Akorn Animal Health, Inc.
![Tolazine (Tolazoline Hydrochloride) Injection, Solution [Akorn Animal Health, Inc.]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Tolazine | Akorn Animal Health, Inc.
The Tolazine dose is 4.0 mg/kg body weight or 1.8 mg/lb (4 mL/100 kg or 4 mL/220 lb) to reverse the sedative effects of xylazine. The carefully calculated dose of Tolazine should be given slowly by intravenous injection. Administration rate should approximate 1 mL/second.1,5
The table demonstrates the correct injection volume based on body weight:
Body Weight (kg) Body Weight (lb) Tolazine Injection Volume 250 kg 550 lb 10 mL 500 kg 1100 lb 20 mL -
Lloyd Inc. Of Iowa
Tolazine | Lloyd Inc. Of Iowa
The Tolazine dose is 4.0 mg/kg body weight or 1.8 mg/lb (4 mL/100 kg or 4 mL/220 lb) to reverse the sedative effects of xylazine. The carefully calculated dose of Tolazine should be given slowly by intravenous injection. Administration rate should approximate 1 mL/second.1,5
The table demonstrates the correct injection volume based on body weight:
Body Weight (kg) Body Weight (lb) Tolazine Injection Volume 250 kg 550 lb 10 mL 500 kg 1100 lb 20 mL
![Tolazine (Tolazoline Hydrochloride) Injection [Lloyd Inc. Of Iowa]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=0b94baa5-5af2-46e9-8111-519225206a28&name=tolazine-02.jpg)
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