Up And Up Ibuprofen Pm
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Questions & Answers
Side Effects & Adverse Reactions
For use in animals only. In rare instances, use of this product in cats has been associated with Retinal Toxicity. Do not exceed 5 mg/kg of body weight per day in cats. Safety in breeding or pregnant cats has not been established. Keep out of reach of children.
Avoid contact with eyes. In case of contact, immediately flush eyes with copious amounts of water for 15 minutes. In case of dermal contact, wash skin with soap and water. Consult a physician if irritation persists following ocular or dermal exposure. Individuals with a history of hypersensitivity to quinolones should avoid this product. In humans, there is a risk of user photosensitization within a few hours after excessive exposure to quinolones. If excessive accidental exposure occurs, avoid direct sunlight.
For customer service or to obtain product information, including Material Safety Data Sheet, call 1-800-637-0281.
Legal Issues
There is currently no legal information available for this drug.
FDA Safety Alerts
There are currently no FDA safety alerts available for this drug.
Manufacturer Warnings
There is currently no manufacturer warning information available for this drug.
FDA Labeling Changes
There are currently no FDA labeling changes available for this drug.
Uses
Zobuxa™ (enrofloxacin) Flavored Antibacterial Tablets are indicated for the management of diseases associated with bacteria susceptible to enrofloxacin. Zobuxa Flavored Antibacterial Tablets are indicated for use in dogs and cats.
Dogs: Clinical efficacy was established in dermal infections (wounds and abscesses) associated with susceptible strains of Escherichia coli, Klebsiella pneumonia, Proteus mirabilis, and Staphylococcus intermedius; respiratory infections (pneumonia, tonsillitis, rhinitis) associated with susceptible strains of Escherichia coli and Staphylococcus aureus; and urinary cystitis associated with susceptible strains of Escherichia coli, Proteus mirabilis, and Staphylococcus aureus.
Cats: Clinical efficacy was established in dermal infections (wounds and abscesses) associated with susceptible strains ofPasteurella multocida, Staphylococcus aureus, and Staphylococcus epidermidis.
History
There is currently no drug history available for this drug.
Other Information
Enrofloxacin is a synthetic chemotherapeutic agent from the class of the quinolone carboxylic acid derivatives. It has antibacterial activity against a broad spectrum of Gram negative and Gram positive bacteria (See Tables I and II). It is rapidly absorbed from the digestive tract, penetrating into all measured body tissues and fluids (See Table III). Tablets are available in four tablet sizes (22.7, 68, 136 and 272 mg enrofloxacin).
CHEMICAL NOMENCLATURE AND STRUCTURAL FORMULA:
1-cyclopropyl-7-(4-ethyl-1-piperazinyl)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid.
Sources
Up And Up Ibuprofen Pm Manufacturers
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Target Corporation
![Up And Up Ibuprofen Pm (Diphenhydramine Citrate And Ibuprofen) Tablet, Coated [Target Corporation]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Up And Up Ibuprofen Pm | Novartis Animal Health Us, Inc.
Dogs: Administer orally at a rate to provide 5-20 mg/kg (2.27 to 9.07 mg/lb) of body weight. Selection of a dose within this range should be based on clinical experience, the severity of disease, and susceptibility of the pathogen. Animals which receive doses in the upper-end of the dose range should be carefully monitored for clinical signs that may include inappetence, depression, and vomition.
Weight of Dog
Once Daily Dosing Chart
5 mg/kg
10 mg/kg
15 mg/kg
20 mg/kg
9.1 kg (20 lb)
2 x 22.7 mg tablets
1 x 22.7 mg plus
1 x 68 mg tablets1 x 136 mg tablet
or
0.5 x 272 mg tablet1 x 136 mg plus
2 x 22.7 mg tablets
or
0.5 x 272 mg plus
2 x 22.7 mg tablet27.2 kg (60 lb)
1 x 136 mg tablet
or
0.5 x 272 mg tablet2 x 136 mg tablets
or
1 x 272 mg tablet3 x 136 mg tablets
or
1.5 x 272 mg tablets4 x 136 mg tablets
or
2 x 272 mg tablets54.4 kg (120 lb)
2 x 136 mg tablets
or
1 x 272 mg tablets4 x 136 mg tablets
or
2 x 272 mg tablets6 x 136 mg tablets
or
3 x 272 mg tablets8 x 136 mg tablets
or
4 x 272 mg tabletsAll tablet sizes are doubled scored (a score on either side of the tablet) for accurate dosing.
Cats: Administer orally at 5 mg/kg (2.27 mg/lb) of body weight. The dose for dogs and cats may be administered either as a single daily dose or divided into two (2) equal daily doses administered at twelve (12) hour intervals. The dose should be continued for at least 2-3 days beyond cessation of clinical signs, to a maximum of 30 days.
Weight of Cat
Once Daily Dosing Chart
(5 mg/kg/day)5 lb (2.27 kg)
1/2 x 22.7 mg tablet
10 lb (4.5 kg)
1 x 22.7 mg tablet
15 lb (6.8 kg)
1 and 1/2 x 22.7 mg tablets
or
1/2 x 68 mg tabletAll tablet sizes are doubled scored (a score on either side of the tablet) for accurate dosing.
Dogs & Cats: The duration of treatment should be selected based on clinical evidence. Generally, administration of Zobuxa Tablets should continue for at least 2-3 days beyond cessation of clinical signs. For severe and/or complicated infections, more prolonged the- rapy, up to 30 days, may be required. If no improvement is seen within five days, the diagnosis should be reevaluated and a different course of therapy considered.
The lower limit of the dose range in dogs and the daily dose for cats was based on efficacy studies in dogs and cats where enrofloxa- cin was administered at 2.5 mg/kg twice daily. Target animal safety and toxicology were used to establish the upper limit of the dose range for dogs and treatment duration for dogs and cats.
STORAGE:Dispense tablets in tight containers only.
Store at 20°C to 25°C (68°F to 77°F); excursions permitted between 15°C and 30°C (between 59°F and 86°F) [See USP Controlled Room Temperature].
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Target Corporation
Up And Up Ibuprofen Pm | Target Corporation
do not take more than directed adults and children 12 years and over: take 2 caplets at bedtime do not take more than 2 caplets in 24 hours
![Up And Up Ibuprofen Pm (Diphenhydramine Citrate, Ibuprofen) Tablet, Coated [Target Corporation]](http://dailymed.nlm.nih.gov/dailymed/image.cfm?setid=4edb9e53-7b1f-4273-bf27-9b069c7e8fa2&name=739e139b-e06c-423c-948a-50b0ba51ba1b-01.jpg)
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