Vetstarch
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Manufacturer Warnings
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FDA Labeling Changes
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Uses
VetStarch™ (6% hydroxyethyl starch 130/0.4 in 0.9% sodium chloride injection) is indicated for the treatment and prophylaxis of hypovolemia. It is not a substitute for red blood cells or coagulation factors in plasma.
History
There is currently no drug history available for this drug.
Other Information
VetStarch™ (6% hydroxyethyl starch 130/0.4 in 0.9% sodium chloride injection) is a clear to slightly opalescent, colorless to slightly yellow, sterile, non-pyrogenic, isotonic solution for intravenous administration using sterile equipment.
Each 100 mL of the solution contains:
| Hydroxyethyl Starch 130/0.4 | 6 g |
| Sodium Chloride USP in Water for Injection USP | 900 mg |
| pH adjusted with Sodium Hydroxide USP or Hydrochloric Acid USP | |
Electrolytes (mEq/L): Sodium 154, Chloride 154, pH 4 to 5.5. Calculated osmolarity 308 mOsmol/L. The hydroxyethyl starch contained in VetStarch is a synthetic colloid for use in plasma volume replacement. The chemical name of hydroxyethyl starch is poly(O-2-hydroxyethyl) starch. The structural formula of hydroxyethyl starch is:
VetStarch is packaged in 250 mL and 500 mL flexible plastic containers made from coextruded polyolefin and is free of PVC, plasticizers, adhesives or latex (Non-DEHP, Latex-free). The container offers an air-closed system and can be used with nonvented IV sets which prevent external air contamination. The container is collapsible and can be used in emergency cases for pressure infusion.
Sources
Vetstarch Manufacturers
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Abbott Laboratories
![Vetstarch (Hydroxyethyl Starch 130/0.4 Substitution) Injection, Solution [Abbott Laboratories]](/wp-content/themes/bootstrap/assets/img/loading2.gif)
Vetstarch | Abbott Laboratories
VetStarch is administered by intravenous infusion only. The daily dose and rate of infusion depend on the patient’s blood loss, on the maintenance or restoration of hemodynamics and on the hemodilution (dilution effect). VetStarch can be administered repetitively over several days. [See Warnings and Precautions (5)]
2.1 Adult Dose
The initial 10 to 20 mL should be infused slowly, keeping the patient under close observation due to possible anaphylactoid reactions. [see General Warnings and Precautions (5.1)]As a general recommendation, the class of synthetic colloids are prescribed at doses up to 20 mL per kg of body weight per day in small animal patients.1 In a 30 kg patient, this is a dose of 600 mL of VetStarch (equivalent to 1.2 g hydroxyethyl starch and 3.1 mEq sodium per kg of body weight). The use of 6% hydroxyethyl starch 130/0.4 has been dosed at 50 mL per kg of body weight per day in human studies.2
2.2 Directions for Use of VetStarch1. Do not remove the IV container from its overwrap until immediately before use.
2. Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit.
3. Do not administer unless the solution is clear, free from particles and the IV container is undamaged.
4. VetStarch should be used immediately after insertion of the administration set.
5. Do not vent.
6. If administered by pressure infusion, air should be withdrawn or expelled from the bag through the medication/administration port prior to infusion.
7. Discontinue the infusion if an adverse reaction occurs.
8. It is recommended that administration sets be changed at least once every 24 hours.
9. For single use only. Discard unused portion.INCOMPATIBILITIES
The safety and compatibility of additives have not been established.
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